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Journal of Biomedicine and Biotechnology
Volume 2006 (2006), Article ID 27012, 6 pages
http://dx.doi.org/10.1155/JBB/2006/27012
Research Article

The Adipose Renin-Angiotensin System Modulates Systemic Markers of Insulin Sensitivity and Activates the Intrarenal Renin-Angiotensin System

1Department of Nutrition and Agricultural Experiment Station, University of Tennessee, Knoxville, TN 37996, USA
2Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
3Centre Biomédical des Cordeliers, INSERM U671-IFR58, Paris 75270, France
4Centre de Biochimie, CNRS 6543, Nice 06108, France

Received 6 April 2006; Revised 17 July 2006; Accepted 18 July 2006

Copyright © 2006 Suyeon Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The adipose tissue renin-angiotensin system (RAS) contributes to regulation of fat mass and may also impact systemic functions such as blood pressure and metabolism. Methods and results. A panel of mouse models including mice lacking angiotensinogen, Agt (Agt-KO), mice expressing Agt solely in adipose tissue (aP2-Agt/Agt-KO), and mice overexpressing Agt in adipose tissue (aP2-Agt) was studied. Total body weight, epididymal fat pad weight, and circulating levels of leptin, insulin, and resistin were significantly decreased in Agt-KO mice, while plasma adiponectin levels were increased. aP2-Agt mice exhibited increased adiposity and plasma leptin and insulin levels compared to wild type (WT) controls. Angiotensinogen and type I Ang II receptor protein levels were also elevated in kidney of aP2-Agt mice. Conclusion. These findings demonstrate that alterations in adipose RAS activity significantly impact both local and systemic physiology in a way that may contribute to the detrimental health effects of obesity.