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Journal of Biomedicine and Biotechnology
Volume 2006 (2006), Article ID 31825, 11 pages
Dysregulation of Protein Phosphorylation/Dephosphorylation in Alzheimer's Disease: A Therapeutic Target
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314-6399, USA
Received 8 November 2005; Revised 12 December 2005; Accepted 3 January 2006
Copyright © 2006 Cheng-Xin Gong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [36 citations]
The following is the list of published articles that have cited the current article.
- Fei Liu, Bin Li, E-Jan Tung, Inge Grundke-Iqbal, Khalid Iqbal, and Cheng-Xin Gong, “Site-specific effects of tau phosphorylation on its microtubule assembly ac tivity and self-aggregation,” European Journal of Neuroscience, vol. 26, no. 12, pp. 3429–3436, 2007.
- Jiang Fang, Rong Liu, Qing Tian, Xiao-ping Hong, Shao-hui Wang, Fu-yuan Cao, Xi-ping Pan, and Jian-zhi Wang, “Dehydroevodiamine attenuates calyculin A-induced tau hyperphos-phorylation in rat brain slices,” Acta Pharmacologica Sinica, vol. 28, no. 11, pp. 1717–1723, 2007.
- Fei Liu, Zhihou Liang, Jerzy Wegiel, Yu-Wen Hwang, Khalid Iqbal, Inge Grundke-Iqbal, Narayan Ramakrishna, and Cheng-Xin Gong, “Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Dow n syndrome,” Faseb Journal, vol. 22, no. 9, pp. 3224–3233, 2008.
- Carla L. Busceti, Francesca Biagioni, Barbara Riozzi, Giuseppe Battaglia, Marianna Storto, Carlo Cinque, Gemma Molinaro, Roberto Gradini, Andrea Caricasole, Anna Maria Canudas, Valeria Bruno, Ferdinando Nicoletti, and Francesco Fornai, “Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-me thylenedioxymethamphetamine ("Ecstasy"),” Journal of Neuroscience, vol. 28, no. 12, pp. 3234–3245, 2008.
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- Bo Su, Xinglong Wang, Kelly L. Drew, George Perry, Mark A. Smith, and Xiongwei Zhu, “Physiological regulation of tau phosphorylation during hibernation,” Journal of Neurochemistry, vol. 105, no. 6, pp. 2098–2108, 2008.
- Sul-Hee Chung, “Aberrant phosphorylation in the pathogenesis of Alzheimer's disease,” Bmb Reports, vol. 42, no. 8, pp. 467–474, 2009.
- Yang Yu, Xiaoqin Run, Zhihou Liang, Yi Li, Fei Liu, Ying Liu, Khalid Iqbal, Inge Grundke-Iqbal, and Cheng-Xin Gong, “Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases,” Journal of Neurochemistry, vol. 108, no. 6, pp. 1480–1494, 2009.
- Jy Yang Jiang-Yong, Jl Gu Jian-Lan, Jh Shi Jian-Hua, F Liu Fei, and Q Shen Qin, “The Inhibitory Effect of OGT Gene Expression on The Level of tau Phosphoryl ation,” Progress in Biochemistry and Biophysics, vol. 36, no. 3, pp. 346–352, 2009.
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- Yanqiu Deng, Bin Li, Ying Liu, Khalid Iqbal, Inge Grundke-Iqbal, and Cheng-Xin Gong, “Dysregulation of Insulin Signaling, Glucose Transporters, O-GlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain,” The American Journal of Pathology, vol. 175, no. 5, pp. 2089–2098, 2009.
- Magdalena Kuszczyk, Wanda Gordon-Krajcer, and Jerzy W. Lazarewicz, “Homocysteine-induced acute excitotoxicity in cerebellar granule cells in vitro is accompanied by PP2A-mediated dephosphorylation of tau,” Neurochemistry International, vol. 55, no. 1-3, pp. 174–180, 2009.
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- Matthew J. Chiocco, Xuguang Zhu, Donna Walther, Olga Pletnikova, Juan C. Troncoso, George R. Uhl, and Qing-Rong Liu, “Fine Mapping of Calcineurin (PPP3CA) Gene Reveals Novel Alternative Splicin g Patterns, Association of 5 ' UTR Trinucleotide Repeat With Addiction Vuln erability, and Differential Isoform Expression in Alzheimer's Disease,” Substance Use & Misuse, vol. 45, no. 11, pp. 1809–1826, 2010.
- Khalid Iqbal, and Inge Grundke-Iqbal, “Alzheimer's disease, a multifactorial disorder seeking multitherapies,” Alzheimers & Dementia, vol. 6, no. 5, pp. 420–424, 2010.
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- Zhang Zhang, and James W. Simpkins, “Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner,” Brain Research, vol. 1345, pp. 176–181, 2010.
- Bo Su, Xinglong Wang, David Bonda, Gorge Perry, Mark Smith, and Xiongwei Zhu, “Abnormal Mitochondrial Dynamics-A Novel Therapeutic Target for Alzheimer's Disease?,” Molecular Neurobiology, vol. 41, no. 2-3, pp. 87–96, 2010.
- Malgorzata Broncel, Jessica A. Falenski, Sara C. Wagner, Christian P. R. Hackenberger, and Beate Koksch, “How Post-Translational Modifications Influence Amyloid Formation: A Systematic Study of Phosphorylation and Glycosylation in Model Peptides,” Chemistry - A European Journal, vol. 16, no. 26, pp. 7881–7888, 2010.
- Jian-Jung Pan, Boris A. Kashemirov, Joanne Lee, Charles E. McKenna, Frank J. Devlin, and Philip J. Stephens, “Electronic circular dichroism of monomethyl [16O,17O,18O]-phosphate and [16O,17O,18O]-thiophosphate revisited,” Bioorganic Chemistry, vol. 38, no. 1, pp. 7–16, 2010.
- Scott A. Smith, Christine L. Kalcic, Kyle A. Safran, Paul M. Stemmer, Marcos Dantus, and Gavin E. Reid, “Enhanced Characterization of Singly Protonated Phosphopeptide Ions by Femto second Laser-induced Ionization/Dissociation Tandem Mass Spectrometry (fs-L ID-MS/MS),” Journal of The American Society for Mass Spectrometry, vol. 21, no. 12, pp. 2031–2040, 2010.
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- Julie Allyson, Eve Dontigny, Yves Auberson, Michel Cyr, and Guy Massicotte, “Blockade of NR2A-Containing NMDA Receptors Induces Tau Phosphorylation in Rat Hippocampal Slices,” Neural Plasticity, vol. 2010, pp. 1–10, 2010.
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- Saadia Zahid, Michael Oellerich, Abdul R Asif, and Nikhat Ahmed, “Phosphoproteome profiling of substantia nigra and cortex regions of Alzheimer’s disease patients,” Journal of Neurochemistry, vol. 121, no. 6, pp. 954–963, 2012.
- Tiago Silva, José Teixeira, Fernando Remião, and Fernanda Borges, “Alzheimersche Demenz, Cholesterin und Statine: Berührungspunkte wichtiger Stoffwechselwege,” Angewandte Chemie, vol. 125, no. 4, pp. 1146–1158, 2012.
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