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Journal of Biomedicine and Biotechnology
Volume 2006 (2006), Article ID 31825, 11 pages
Dysregulation of Protein Phosphorylation/Dephosphorylation in Alzheimer's Disease: A Therapeutic Target
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314-6399, USA
Received 8 November 2005; Revised 12 December 2005; Accepted 3 January 2006
Copyright © 2006 Cheng-Xin Gong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [39 citations]
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- Fei Liu, Bin Li, E-Jan Tung, Inge Grundke-Iqbal, Khalid Iqbal, and Cheng-Xin Gong, “Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation,” European Journal Of Neuroscience, vol. 26, no. 12, pp. 3429–3436, 2007.
- Jiang Fang, Rong Liu, Qing Tian, Xiao-ping Hong, Shao-hui Wang, Fu-yuan Cao, Xi-ping Pan, and Jian-zhi Wang, “Dehydroevodiamine attenuates calyculin A-induced tau hyperphos-phorylation in rat brain slices,” Acta Pharmacologica Sinica, vol. 28, no. 11, pp. 1717–1723, 2007.
- Fei Liu, Zhihou Liang, Jerzy Wegiel, Yu-Wen Hwang, Khalid Iqbal, Inge Grundke-Iqbal, Narayan Ramakrishna, and Cheng-Xin Gong, “Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome,” Faseb Journal, vol. 22, no. 9, pp. 3224–3233, 2008.
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- Amy Y. Chan, Ayat Alsaraby, and Thomas B. Shea, “Folate deprivation increases tau phosphorylation by homocysteine-induced calcium influx and by inhibition of phosphatase activity: Alleviation by S-adenosyl methionine,” Brain Research, vol. 1199, pp. 133–137, 2008.
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