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Journal of Biomedicine and Biotechnology
Volume 2006 (2006), Article ID 31825, 11 pages
Dysregulation of Protein Phosphorylation/Dephosphorylation in Alzheimer's Disease: A Therapeutic Target
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314-6399, USA
Received 8 November 2005; Revised 12 December 2005; Accepted 3 January 2006
Copyright © 2006 Cheng-Xin Gong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [36 citations]
The following is the list of published articles that have cited the current article.
- Fei Liu, Bin Li, E-Jan Tung, Inge Grundke-Iqbal, Khalid Iqbal, and Cheng-Xin Gong, “Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation,” European Journal Of Neuroscience, vol. 26, no. 12, pp. 3429–3436, 2007.
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- Fei Liu, Zhihou Liang, Jerzy Wegiel, Yu-Wen Hwang, Khalid Iqbal, Inge Grundke-Iqbal, Narayan Ramakrishna, and Cheng-Xin Gong, “Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome,” Faseb Journal, vol. 22, no. 9, pp. 3224–3233, 2008.
- Carla L. Busceti, Francesca Biagioni, Barbara Riozzi, Giuseppe Battaglia, Marianna Storto, Carlo Cinque, Gemma Molinaro, Roberto Gradini, Andrea Caricasole, Anna Maria Canudas, Valeria Bruno, Ferdinando Nicoletti, and Francesco Fornai, “Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy"),” Journal Of Neuroscience, vol. 28, no. 12, pp. 3234–3245, 2008.
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- Yang Yu, Xiaoqin Run, Zhihou Liang, Yi Li, Fei Liu, Ying Liu, Khalid Iqbal, Inge Grundke-Iqbal, and Cheng-Xin Gong, “Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases,” Journal of Neurochemistry, vol. 108, no. 6, pp. 1480–1494, 2009.
- Jy Yang Jiang-Yong, Jl Gu Jian-Lan, Jh Shi Jian-Hua, F Liu Fei, and Q Shen Qin, “The Inhibitory Effect of OGT Gene Expression on The Level of tau Phosphorylation,” Progress In Biochemistry And Biophysics, vol. 36, no. 3, pp. 346–352, 2009.
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- Yanqiu Deng, Bin Li, Ying Liu, Khalid Iqbal, Inge Grundke-Iqbal, and Cheng-Xin Gong, “Dysregulation of Insulin Signaling, Glucose Transporters, O-GlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain,” The American Journal of Pathology, vol. 175, no. 5, pp. 2089–2098, 2009.
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- Khalid Iqbal, and Inge Grundke-Iqbal, “Alzheimer's disease, a multifactorial disorder seeking multitherapies,” Alzheimers & Dementia, vol. 6, no. 5, pp. 420–424, 2010.
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- Matthew J. Chiocco, Xuguang Zhu, Donna Walther, Olga Pletnikova, Juan C. Troncoso, George R. Uhl, and Qing-Rong Liu, “Fine Mapping of Calcineurin (PPP3CA) Gene Reveals Novel Alternative Splicing Patterns, Association of 5 ' UTR Trinucleotide Repeat With Addiction Vulnerability, and Differential Isoform Expression in Alzheimer's Disease,” Substance Use & Misuse, vol. 45, no. 11, pp. 1809–1826, 2010.
- Zhang Zhang, and James W. Simpkins, “Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner,” Brain Research, vol. 1345, pp. 176–181, 2010.
- Bo Su, Xinglong Wang, David Bonda, Gorge Perry, Mark Smith, and Xiongwei Zhu, “Abnormal Mitochondrial Dynamics-A Novel Therapeutic Target for Alzheimer's Disease?,” Molecular Neurobiology, vol. 41, no. 2-3, pp. 87–96, 2010.
- Malgorzata Broncel, Jessica A. Falenski, Sara C. Wagner, Christian P. R. Hackenberger, and Beate Koksch, “How Post-Translational Modifications Influence Amyloid Formation: A Systematic Study of Phosphorylation and Glycosylation in Model Peptides,” Chemistry - A European Journal, vol. 16, no. 26, pp. 7881–7888, 2010.
- Jian-Jung Pan, Boris A. Kashemirov, Joanne Lee, Charles E. McKenna, Frank J. Devlin, and Philip J. Stephens, “Electronic circular dichroism of monomethyl [16O,17O,18O]-phosphate and [16O,17O,18O]-thiophosphate revisited,” Bioorganic Chemistry, vol. 38, no. 1, pp. 7–16, 2010.
- Scott A. Smith, Christine L. Kalcic, Kyle A. Safran, Paul M. Stemmer, Marcos Dantus, and Gavin E. Reid, “Enhanced Characterization of Singly Protonated Phosphopeptide Ions by Femtosecond Laser-induced Ionization/Dissociation Tandem Mass Spectrometry (fs-LID-MS/MS),” Journal Of The American Society For Mass Spectrometry, vol. 21, no. 12, pp. 2031–2040, 2010.
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- Julie Allyson, Eve Dontigny, Yves Auberson, Michel Cyr, and Guy Massicotte, “Blockade of NR2A-Containing NMDA Receptors Induces Tau Phosphorylation in Rat Hippocampal Slices,” Neural Plasticity, vol. 2010, pp. 1–10, 2010.
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