About this Journal Submit a Manuscript Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2006 (2006), Article ID 35936, 11 pages
http://dx.doi.org/10.1155/JBB/2006/35936
Review Article

The Creatine Kinase/Creatine Connection to Alzheimer's Disease: CK Inactivation, APP-CK Complexes and Focal Creatine Deposits

1Institute of Cell Biology, ETH Zurich, Hönggerberg HPM, Zurich CH-8093, Switzerland
2INSERM E0221, Laboratory of Fundamental and Applied Bioenergetics, University Joseph Fourier, Grenoble, France
3Department of Neurology, University of Tennessee Health Science Center, Memphis 38163, TN, USA
4Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2

Received 12 December 2005; Revised 28 February 2006; Accepted 28 February 2006

Copyright © 2006 Tanja S. Bürklen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [34 citations]

The following is the list of published articles that have cited the current article.

  • John T. Brosnan, and Margaret E. Brosnan, “Creatine: Endogenous Metabolite, Dietary, and Therapeutic Supplement,” Annual Review of Nutrition, vol. 27, no. 1, pp. 241–261, 2007. View at Publisher · View at Google Scholar
  • Robert H. Andres, Angélique D. Ducray, Uwe Schlattner, Theo Wallimann, and Hans Rudolf Widmer, “Functions and effects of creatine in the central nervous system,” Brain Research Bulletin, vol. 76, no. 4, pp. 329–343, 2008. View at Publisher · View at Google Scholar
  • Murali Jayaraman, Gomathi Kannayiram, and Jayakumar Rajadas, “Amyloid toxicity in skeletal myoblasts: Implications for inclusion-body myositis,” Archives of Biochemistry and Biophysics, vol. 474, no. 1, pp. 15–21, 2008. View at Publisher · View at Google Scholar
  • Shan Feng, Zhen Xu, and Yong-Bin Yan, “Blocking creatine kinase refolding by trace amounts of copper ions,” Journal of Inorganic Biochemistry, vol. 102, no. 4, pp. 928–935, 2008. View at Publisher · View at Google Scholar
  • Jacqueline Vazquez, Steven C. Hall, H. Ewa Witkowska, and Mary Ann Greco, “Rapid Alterations in Cortical Protein Profiles Underlie Spontaneous Sleep a nd Wake Bouts,” Journal of Cellular Biochemistry, vol. 105, no. 6, pp. 1472–1484, 2008. View at Publisher · View at Google Scholar
  • Bruno Gualano, Carlos Ugrinowitsch, Antonio Carlos Seguro, and Antonio Herbert Lancha Jr., “Does creatine supplementation harm renal function?,” Revista Brasileira de Medicina do Esporte, vol. 14, no. 1, pp. 68–73, 2008. View at Publisher · View at Google Scholar
  • Peter J. Adhihetty, and M. Flint Beal, “Creatine and Its Potential Therapeutic Value for Targeting Cellular Energy Impairment in Neurodegenerative Diseases,” Neuromolecular Medicine, vol. 10, no. 4, pp. 275–290, 2008. View at Publisher · View at Google Scholar
  • Lichuan Yang, Noel Y. Calingasan, Elizabeth J. Wille, Kerry Cormier, Karen Smith, Robert J. Ferrante, and M. Flint Beal, “ Combination therapy with Coenzyme Q 10 and creatine produces additive neuroprotective effects in models of Parkinson’s and Huntington’s Diseases ,” Journal of Neurochemistry, vol. 109, no. 5, pp. 1427–1439, 2009. View at Publisher · View at Google Scholar
  • Yafeng Zhang, Hai Li, Xiaoming Wang, Xiang Gao, and Xiaolong Liu, “Regulation of T cell development and activation by creatine kinase B,” PLoS ONE, vol. 4, no. 4, 2009. View at Publisher · View at Google Scholar
  • Nadirah Ghenimi Rahab, Marie-Christine Beauvieux, Marc Biran, Veronique Pallet, Paul Higueret, and Jean-Louis Gallis, “Vitamin A Deficiency in Rats Induces Anatomic and Metabolic Changes Compara ble with Those of Neurodegenerative Disorders,” Journal of Nutrition, vol. 139, no. 4, pp. 696–702, 2009. View at Publisher · View at Google Scholar
  • Ilenia Bazzucchi, Francesco Felici, and Massimo Sacchetti, “Effect of Short-Term Creatine Supplementation on Neuromuscular Function,” Medicine and Science in Sports and Exercise, vol. 41, no. 10, pp. 1934–1941, 2009. View at Publisher · View at Google Scholar
  • Maurizio Balestrino, Carlo Gandolfo, and Luisa Perasso, “Controlling the flow of energy: Inhibition and stimulation of the creatine transporter,” Current Enzyme Inhibition, vol. 5, no. 4, pp. 223–233, 2009. View at Publisher · View at Google Scholar
  • Stephen T. Hammett, Matthew B. Wall, Thomas C. Edwards, and Andrew T. Smith, “Dietary supplementation of creatine monohydrate reduces the human fMRI BOLD signal,” Neuroscience Letters, vol. 479, no. 3, pp. 201–205, 2010. View at Publisher · View at Google Scholar
  • Seung-Ah Park, Hye Won Park, Nam-Hee Kim, Yoon-Ha Kim, Min-Jeong Kwak, Jun-Seop Shin, and Chan-Wha Kim, “Effects of Tau on the activity of triose phosphate isomerase (TPI) in brain cells,” Neurochemistry International, vol. 56, no. 8, pp. 886–892, 2010. View at Publisher · View at Google Scholar
  • Valdur Saks, Rita Guzun, Natalja Timohhina, Kersti Tepp, Minna Varikmaa, Claire Monge, Nathalie Beraud, Tuuli Kaambre, Andrey Kuznetsov, Lumme Kadaja, Margus Eimre, and Enn Seppet, “Structure–function relationships in feedback regulation of energy fluxes in vivo in health and disease: Mitochondrial Interactosome,” Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol. 1797, no. 6-7, pp. 678–697, 2010. View at Publisher · View at Google Scholar
  • Elmar Kaiser, Peter Schoenknecht, Stefan Kassner, Wulf Hildebrandt, Ralf Kinscherf, and Johannes Schroeder, “Cerebrospinal fluid concentrations of functionally important amino acids and metabolic compounds in patients with mild cognitive impairment and Alzheimer's disease,” Neurodegenerative Diseases, vol. 7, no. 4, pp. 251–259, 2010. View at Publisher · View at Google Scholar
  • Elidie Beard, and Olivier Braissant, “Synthesis and transport of creatine in the CNS: importance for cerebral fun ctions,” Journal of Neurochemistry, vol. 115, no. 2, pp. 297–313, 2010. View at Publisher · View at Google Scholar
  • Zhang, Hennessey, Yang, Starkova, Beal, and Starkov, “Impaired brain creatine kinase activity in Huntington's disease,” Neurodegenerative Diseases, vol. 8, no. 4, pp. 194–201, 2011. View at Publisher · View at Google Scholar
  • N. Timohhina, R. Guzun, T. Kaambre, A. V. Kuznetsov, M. Gonzalez-Granillo, V. Chekulayev, K. Tepp, V. A. Saks, and I. Shevchuk, “Systems bioenergetics of creatine kinase networks: physiological roles of c reatine and phosphocreatine in regulation of cardiac cell function,” Amino Acids, vol. 40, no. 5, pp. 1333–1348, 2011. View at Publisher · View at Google Scholar
  • Nersesova, “Role of creatine kinase and its substrates in the central nervous system in norm and in various pathologies,” Journal of Evolutionary Biochemistry and Physiology, vol. 47, no. 2, pp. 140–150, 2011. View at Publisher · View at Google Scholar
  • J. Dulinska, Z. Setkowicz, K. Janeczko, C. Sandt, P. Dumas, L. Uram, K. Gzielo-Jurek, and J. Chwiej, “Synchrotron radiation Fourier-transform infrared and Raman microspectroscopy study showing an increased frequency of creatine inclusions in the rat hippocampal formation following pilocarpine-induced seizures,” Analytical and Bioanalytical Chemistry, vol. 402, no. 7, pp. 2267–2274, 2011. View at Publisher · View at Google Scholar
  • Jie Cui, Mei Yu, Jingwen Niu, Zhenyu Yue, and Zhiheng Xu, “Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system,” Bioscience Reports, vol. 31, no. 5, pp. 429–437, 2011. View at Publisher · View at Google Scholar
  • Wei-Jiang Hu, Sheng-Mei Zhou, Joshua SungWoo Yang, and Fan-Guo Meng, “Computational Simulations to Predict Creatine Kinase-Associated Factors: Protein-Protein Interaction Studies of Brain and Muscle Types of Creatine Kinases,” Enzyme Research, vol. 2011, pp. 1–12, 2011. View at Publisher · View at Google Scholar
  • Leonardo Magno Rambo, Michele Rechia Fighera, Luiz Fernando Freire Royes, Leandro Rodrigo Ribeiro, Vanessa Grigoletto Schramm, Andriely Moreira Berch, Daniel Neis Stamm, Iuri Domingues Della-Pace, Luiz Fernando Almeida Silva, Ana Flávia Furian, and Mauro Schneider Oliveira, “Creatine increases hippocampal Na+,K+-ATPase activity via NMDA-calcineurin pathway,” Brain Research Bulletin, vol. 88, no. 6, pp. 553–559, 2012. View at Publisher · View at Google Scholar
  • Zhe Chen, Xiang-Jun Chen, Mengdie Xia, Hua-Wei He, Sha Wang, Huihui Liu, Haipeng Gong, and Yong-Bin Yan, “Chaperone-Like Effect of the Linker on the Isolated C-Terminal Domain of Ra bbit Muscle Creatine Kinase,” Biophysical Journal, vol. 103, no. 3, pp. 558–566, 2012. View at Publisher · View at Google Scholar
  • Yuko Kurosawa, Ton J. DeGrauw, Diana M. Lindquist, Victor M. Blanco, Gail J. Pyne-Geithman, Takiko Daikoku, James B. Chambers, Stephen C. Benoit, and Joseph F. Clark, “Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency,” Journal of Clinical Investigation, vol. 122, no. 8, pp. 2837–2846, 2012. View at Publisher · View at Google Scholar
  • Patricia J. Allen, “Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value?,” Neuroscience & Biobehavioral Reviews, vol. 36, no. 5, pp. 1442–1462, 2012. View at Publisher · View at Google Scholar
  • Emmanuelle Sarzi, Claire Angebault, Marie Seveno, Naig Gueguen, Benjamin Chaix, Guy Bielicki, Nathalie Boddaert, Anne-Laure Mausset-Bonnefont, Chantal Cazevieille, Valerie Rigau, Jean-Pierre Renou, Jing Wang, Cecile Delettre, Philippe Brabet, Jean-Luc Puel, Christian P. Hamel, Pascal Reynier, and Guy Lenaers, “The human OPA1(delTTAG) mutation induces premature age-related systemic neu rodegeneration in mouse,” Brain, vol. 135, pp. 3599–3613, 2012. View at Publisher · View at Google Scholar
  • Mark J. Hackett, Joonsup Lee, Fatima El-Assaad, James A. McQuillan, Elizabeth A. Carter, Georges E. Grau, Nicholas H. Hunt, and Peter A. Lay, “FTIR Imaging of Brain Tissue Reveals Crystalline Creatine Deposits Are an ex Vivo Marker of Localized Ischemia during Murine Cerebral Malaria: General Implications for Disease Neurochemistry,” ACS Chemical Neuroscience, vol. 3, no. 12, pp. 1017–1024, 2012. View at Publisher · View at Google Scholar
  • Jianyu Feng, Hong Guo, Sen Li, and Tun Lu, “A Study of the Mechanism of the Chaperone-like Function of an scFv of Human Creatine Kinase by Computer Simulation,” PLoS ONE, vol. 8, no. 4, 2013. View at Publisher · View at Google Scholar
  • Ilse S. Pienaar, and Patrick F. Chinnery, “Existing and emerging mitochondrial-targeting therapies for altering Parkinson's disease severity and progression,” Pharmacology & Therapeutics, vol. 137, no. 1, pp. 1–21, 2013. View at Publisher · View at Google Scholar
  • Angelique Camilleri, and Neville Vassallo, “The Centrality of Mitochondria in the Pathogenesis and Treatment of Parkinson's Disease,” CNS Neuroscience & Therapeutics, 2014. View at Publisher · View at Google Scholar
  • Saadia Zahid, Michael Oellerich, and Abdul R. Asif, “Differential Expression of Proteins in Brain Regions of Alzheimer's Disease Patients,” Neurochemical Research, vol. 39, no. 1, pp. 208–215, 2014. View at Publisher · View at Google Scholar
  • Diana Luque-Contreras, Karla Carvajal, Danira Toral-Rios, Diana Franco-Bocanegra, and Victoria Campos-Peña, “Oxidative Stress and Metabolic Syndrome: Cause or Consequence of Alzheimer's Disease?,” Oxidative Medicine and Cellular Longevity, vol. 2014, pp. 1–11, 2014. View at Publisher · View at Google Scholar