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Journal of Biomedicine and Biotechnology
Volume 2006 (2006), Article ID 63675, 9 pages
http://dx.doi.org/10.1155/JBB/2006/63675
Review Article

Targeted Delivery of siRNA

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Room Z735A, PO Box 80082, Utrecht 3508, The Netherlands

Received 16 February 2006; Revised 2 May 2006; Accepted 2 May 2006

Copyright © 2006 Sabrina Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Therapeutic application of siRNA requires delivery to the correct intracellular location, to interact with the RNAi machinery within the target cell, within the target tissue responsible for the pathology. Each of these levels of targeting poses a significant barrier. To overcome these barriers several strategies have been developed, such as chemical modifications of siRNA, viral nucleic acid delivery systems, and nonviral nucleic acid delivery systems. Here, we discuss progress that has been made to improve targeted delivery of siRNA in vivo for each of these strategies.