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Journal of Biomedicine and Biotechnology
Volume 2006 (2006), Article ID 74539, 5 pages
http://dx.doi.org/10.1155/JBB/2006/74539
Review Article

Tau Phosphorylation, Aggregation, and Cell Toxicity

Centro de Biología Molecular “Severo Ochoa”, Facultad de Ciencias, Universidad Autónoma de Madrid, Campus de Cantoblanco, Madrid 28049, Spain

Received 28 November 2005; Revised 16 December 2005; Accepted 3 January 2006

Copyright © 2006 J. Avila et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Protein aggregation takes place in many neurodegenerative disorders. However, there is a controversy about the possible toxicity of these protein aggregates. In this review, this controversy is discussed, focussing on the tau aggregation that takes place in those disorders known as tauopathies.