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Journal of Biomedicine and Biotechnology
Volume 2007 (2007), Article ID 29464, 10 pages
http://dx.doi.org/10.1155/2007/29464
Research Article

Bioengineering of Improved Biomaterials Coatings for Extracorporeal Circulation Requires Extended Observation of Blood-Biomaterial Interaction under Flow

1Department of Cardiothoracic Surgery, Academic Hospital Maastricht, P.O. Box 5800, Maastricht 6200 MD, The Netherlands
2Centre for Biomaterials Research, University of Maastricht, P.O. Box 616, Maastricht 6200 MD, The Netherlands

Received 3 April 2007; Revised 4 July 2007; Accepted 3 December 2007

Academic Editor: John L. McGregor

Copyright © 2007 Kris N. J. Stevens et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. C. Skinner, R. B. Hirschl, and R. H. Bartlett, “Extracorporeal life support,” Seminars in Pediatric Surgery, vol. 15, no. 4, pp. 242–250, 2006. View at Publisher · View at Google Scholar · View at PubMed
  2. O. Mangoush, S. Purkayastha, S. Haj-Yahia, et al., “Heparin-bonded circuits versus nonheparin-bonded circuits: an evaluation of their effect on clinical outcomes,” European Journal of Cardio-Thoracic Surgery, vol. 31, no. 6, pp. 1058–1069, 2007. View at Publisher · View at Google Scholar · View at PubMed
  3. F. D. Rubens, “Cardiopulmonary bypass technology transfer: musings of a cardiac surgeon,” Journal of Biomaterials Science, Polymer Edition, vol. 13, no. 4, pp. 485–499, 2002. View at Publisher · View at Google Scholar
  4. H. P. Wendel and G. Ziemer, “Coating-techniques to improve the hemocompatibility of artificial devices used for extracorporeal circulation,” European Journal of Cardio-Thoracic Surgery, vol. 16, no. 3, pp. 342–350, 1999. View at Publisher · View at Google Scholar
  5. D. Baykut, F. Bernet, J. Wehrle, K. Weichelt, P. Schwartz, and H. R. Zerkowski, “New surface biopolymers for oxygenators: an in vitro hemocompatibility test of poly(2-methoxyethylacrylate),” European Journal of Medical Research, vol. 6, no. 7, pp. 297–305, 2001.
  6. X. M. Mueller, D. Jegger, M. Augustburger, J. Horisberger, and L. K. von Segesser, “Poly 2-methoxyethylacrylate (PMEA) coated oxygenator: an ex vivo study,” International Journal of Artificial Organs, vol. 25, no. 3, pp. 223–229, 2002.
  7. M. Ninomiya, K. Miyaji, and S. Takamoto, “Influence of PMEA-coated bypass circuits on perioperative inflammatory response,” Annals of Thoracic Surgery, vol. 75, no. 3, pp. 913–917, 2003. View at Publisher · View at Google Scholar
  8. J. O'Neill, G. Schutze, M. Heulitt, P. Simpson, and B. Taylor, “Nosocomial infections during extracorporeal membrane oxygenation,” Intensive Care Medicine, vol. 27, no. 8, pp. 1247–1253, 2001. View at Publisher · View at Google Scholar
  9. D. P. Mason, D. J. Boffa, S. C. Murthy, et al., “Extended use of extracorporeal membrane oxygenation after lung transplantation,” Journal of Thoracic and Cardiovascular Surgery, vol. 132, no. 4, pp. 954–960, 2006. View at Publisher · View at Google Scholar · View at PubMed
  10. K. Sung, Y. T. Lee, P. W. Park, et al., “Improved survival after cardiac arrest using emergent autopriming percutaneous cardiopulmonary support,” Annals of Thoracic Surgery, vol. 82, no. 2, pp. 651–656, 2006. View at Publisher · View at Google Scholar · View at PubMed
  11. N. Weber, H. P. Wendel, and G. Ziemer, “Quality assessment of heparin coatings by their binding capacities of coagulation and complement enzymes,” Journal of Biomaterials Applications, vol. 15, no. 1, pp. 8–22, 2000. View at Publisher · View at Google Scholar
  12. D. S. Rijkers, S. J. H. Wielders, G. I. Tesser, and H. C. Hemker, “Design and synthesis of thrombin substrates with modified kinetic parameters,” Thrombosis Research, vol. 79, no. 5-6, pp. 491–499, 1995. View at Publisher · View at Google Scholar
  13. A. B. Chandler, “In vitro thrombotic coagulation of the blood; a method for producing a thrombus,” Laboratory Investigation, vol. 7, no. 2, pp. 110–114, 1958.
  14. R. Kopp, R. Bensberg, A. Kashefi, K. Mottaghy, R. Rossaint, and R. Kuhlen, “Effect of hirudin versus heparin on hemocompatibility of blood contacting biomaterials: an in vitro study,” International Journal of Artificial Organs, vol. 28, no. 12, pp. 1272–1277, 2005.
  15. C. M. Cripps, “Rapid method for the estimation of plasma haemoglobin levels,” Journal of Clinical Pathology, vol. 21, no. 1, pp. 110–112, 1968. View at Publisher · View at Google Scholar
  16. Y. B. J. Aldenhoff, M. L. W. Knetsch, J. H. L. Hanssen, T. Lindhout, S. J. H. Wielders, and L. H. Koole, “Coils and tubes releasing heparin. Studies on a new vascular graft prototype,” Biomaterials, vol. 25, no. 16, pp. 3125–3133, 2004. View at Publisher · View at Google Scholar · View at PubMed
  17. Y. B. J. Aldenhoff, R. Blezer, T. Lindhout, and L. H. Koole, “Photo-immobilisation of dipyridamole (Persantin®) at the surface of polyurethane biomaterials: reduction of in-vitro thrombogenicity,” Biomaterials, vol. 18, no. 2, pp. 167–172, 1997. View at Publisher · View at Google Scholar
  18. T. W. Barrowcliffe, M. Cattaneo, G. M. Podda, et al., “New approaches for measuring coagulation,” Haemophilia, vol. 12, supplement 3, pp. 76–81, 2006. View at Publisher · View at Google Scholar · View at PubMed
  19. W. van Oeveren, J. Haan, P. Lagerman, and P. Schoen, “Comparison of coagulation activity tests in vitro for selected biomaterials,” Artificial Organs, vol. 26, no. 6, pp. 506–511, 2002. View at Publisher · View at Google Scholar
  20. N. Weber, H. P. Wendel, and G. Ziemer, “Hemocompatibility of heparin-coated surfaces and the role of selective plasma protein adsorption,” Biomaterials, vol. 23, no. 2, pp. 429–439, 2002. View at Publisher · View at Google Scholar
  21. G. M. Sreeram, A. D. Sharma, and T. F. Slaughter, “Platelet glycoprotein IIb/IIIa antagonists: perioperative implications,” Journal of Cardiothoracic and Vascular Anesthesia, vol. 15, no. 2, pp. 237–240, 2001. View at Publisher · View at Google Scholar · View at PubMed
  22. C. S. Rinder, J. L. Bonan, H. M. Rinder, J. Mathew, R. Hines, and B. R. Smith, “Cardiopulmonary bypass induces leukocyte-platelet adhesion,” Blood, vol. 79, no. 5, pp. 1201–1205, 1992.
  23. K. T. Lappegård, M. Fung, G. Bergseth, et al., “Effect of complement inhibition and heparin coating on artificial surface-induced leukocyte and platelet activation,” Annals of Thoracic Surgery, vol. 77, no. 3, pp. 932–941, 2004. View at Publisher · View at Google Scholar · View at PubMed
  24. Y.-P. Wu, P. G. de Groot, and J. J. Sixma, “Shear stress-induced detachment of blood platelets from various surfaces,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 17, no. 11, pp. 3202–3207, 1997.
  25. K. Kawahito, J. Mohara, Y. Misawa, and K. Fuse, “Platelet damage caused by the centrifugal pump: in vitro evaluation by measuring the release of α-granule packing proteins,” Artificial Organs, vol. 21, no. 10, pp. 1105–1109, 1997.
  26. V. Kutay, T. Noyan, S. Ozcan, Y. Melek, H. Ekim, and C. Yakut, “Biocompatibility of heparin-coated cardiopulmonary bypass circuits in coronary patients with left ventricular dysfunction is superior to PMEA-coated circuits,” Journal of Cardiac Surgery, vol. 21, no. 6, pp. 572–577, 2006. View at Publisher · View at Google Scholar · View at PubMed
  27. R. A. Malinauskas, “Plasma hemoglobin measurement techniques for the in vitro evaluation of blood damage caused by medical devices,” Artificial Organs, vol. 21, no. 12, pp. 1255–1267, 1997.
  28. R. Ohkawa, Y. Hirowatari, K. Nakamura, et al., “Platelet release of β-thromboglobulin and platelet factor 4 and serotonin in plasma samples,” Clinical Biochemistry, vol. 38, no. 11, pp. 1023–1026, 2005. View at Publisher · View at Google Scholar · View at PubMed
  29. K. T. Lappegård, M. Fung, G. Bergseth, J. Riesenfeld, and T. E. Mollnes, “Artificial surface-induced cytokine synthesis: effect of heparin coating and complement inhibition,” Annals of Thoracic Surgery, vol. 78, no. 1, pp. 38–44, 2004. View at Publisher · View at Google Scholar · View at PubMed
  30. A. E. Åsberg and V. Videm, “Neutrophil dysfunction after biomaterial contact in an in vitro model of cardiopulmonary bypass,” European Journal of Cardio-Thoracic Surgery, vol. 30, no. 5, pp. 744–748, 2006. View at Publisher · View at Google Scholar · View at PubMed
  31. A. E. Åsberg and V. Videm, “Activation of neutrophil granulocytes in an in vitro model of a cardiopulmonary bypass,” Artificial Organs, vol. 29, no. 12, pp. 927–936, 2005. View at Publisher · View at Google Scholar · View at PubMed
  32. J. Gong, R. Larsson, K. N. Ekdahl, T. E. Mollnes, U. Nilsson, and B. Nilsson, “Tubing loops as a model for cardiopulmonary bypass circuits: both the biomaterial and the blood-gas phase interfaces induce complement activation in an in vitro model,” Journal of Clinical Immunology, vol. 16, no. 4, pp. 222–229, 1996. View at Publisher · View at Google Scholar
  33. J. Andersson, J. Sanchez, K. N. Ekdahl, G. Elgue, B. Nilsson, and R. Larsson, “Optimal heparin surface concentration and antithrombin binding capacity as evaluated with human non-anticoagulated blood in vitro,” Journal of Biomedical Materials Research Part A, vol. 67, no. 2, pp. 458–466, 2003. View at Publisher · View at Google Scholar · View at PubMed