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Journal of Biomedicine and Biotechnology
Volume 2007 (2007), Article ID 92385, 3 pages
http://dx.doi.org/10.1155/2007/92385
Case Report

New Complex Chromosomal Translocation in Chronic Myeloid Leukaemia: t(9;18;22)(q34;p11;q11)

1Laboratoire de Cytogénétique, Institut Pasteur du Maroc, Casablanca 20100, Morocco
2Neurosurgery and Neurooncology Section, Surgery Department, Faculty of medicine and health science, University of Shebrooke, Sherbrooke, PQ, Canada J1K2R1
3Laboratoire d'Hématologie-Pr RAPHAEL, Cytogénétique, Pav BROCA - 4ème étage, 78 rue du Général Leclerc, Le Kremlin-Bicetre 94275, France

Received 16 August 2007; Accepted 23 October 2007

Academic Editor: Hatem El Shanti

Copyright © 2007 Abdeljabar El Andaloussi and Chrystele Bilhou-Nabera. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A Chronic myeloid leukaemia (CML) case with a new complex t(9;18;22)(q34;p11;q11) of a 29-year-old man is being reported. For the first time, this translocation has been characterized by karyotype complemented with fluorescence in situ hybridization (FISH). In CML, the complex and standard translocations have the same prognosis. The patient was treated with standard initial therapy based on hydroxyurea before he died due to heart failure four months later. Our finding indicates the importance of combined cytogenetic analysis for diagnosis and guidance of treatment in clinical diagnosis of CML.