About this Journal Submit a Manuscript Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2007 (2007), Article ID 96410, 4 pages
http://dx.doi.org/10.1155/2007/96410
Research Article

Enhancement of a TH1 Immune Response in Amphotericin B-Treated Mucocutaneous Leishmaniasis

Department of Pathology, Faculty of Medicine, University Mayor de San Andrés, Avenue Saavedra 2246, La Paz, Bolivia

Received 6 December 2006; Revised 2 February 2007; Accepted 7 March 2007

Academic Editor: Ali Ouaissi

Copyright © 2007 Washington R. Cuna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In an attempt to investigate the effects of treatment of human leishmaniasis, the cytokines produced by peripheral blood mononuclear cells (PBMCs) of patients with cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL) under treatment with amphotericin B were determined during the active disease from cocultures of cells and Leishmania (Viannia) braziliensis antigens. PBMC of these patients exhibited a nonsignificant marginal increased production of TNF-α upon antigen stimulation. However, under the same antigenic stimulus, patients with active MCL presented higher IFN-γ production compared to patients with CL. This increased IFN-γ production was accompanied by a drastically augmented IL-12 synthesis from cells of MCL patients. The highlighted T cell responses could be relevant for sound control measures of protozoan infections with emphasis on the combined usage of immunoenhancing agents and antiprotozoal drugs.