Enhancement of a <mml:math id="E1" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mtext>T</mml:mtext><mml:mtext>H</mml:mtext></mml:msub></mml:math>1 Immune Response in Amphotericin B-Treated Mucocutaneous Leishmaniasis

Cuna, Washington R.; Velasquez, Rianed; Riva, Janeth; Guachalla, Ingrid; Rodríguez, Celeste

doi:https://doi.org/10.1155/2007/96410

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Immunology and Molecular Biology of Protozoan Infections

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Research Article | Open Access

Volume 2007 | Article ID 096410 | https://doi.org/10.1155/2007/96410

Enhancement of a TH1 Immune Response in Amphotericin B-Treated Mucocutaneous Leishmaniasis

Washington R. Cuna,¹Rianed Velasquez,¹Janeth Riva,¹Ingrid Guachalla,¹and Celeste Rodríguez¹

Academic Editor: Ali Ouaissi

Received06 Dec 2006

Revised02 Feb 2007

Accepted07 Mar 2007

Published10 Jun 2007

Abstract

In an attempt to investigate the effects of treatment of human leishmaniasis, the cytokines produced by peripheral blood mononuclear cells (PBMCs) of patients with cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (MCL) under treatment with amphotericin B were determined during the active disease from cocultures of cells and Leishmania (Viannia) braziliensis antigens. PBMC of these patients exhibited a nonsignificant marginal increased production of TNF-α upon antigen stimulation. However, under the same antigenic stimulus, patients with active MCL presented higher IFN-γ production compared to patients with CL. This increased IFN-γ production was accompanied by a drastically augmented IL-12 synthesis from cells of MCL patients. The highlighted T cell responses could be relevant for sound control measures of protozoan infections with emphasis on the combined usage of immunoenhancing agents and antiprotozoal drugs.

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Copyright © 2007 Washington R. Cuna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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