Infectomic Analysis of Gene Expression Profiles of Human Brain Microvascular Endothelial Cells Infected with Cryptococcus neoformans

Figure 1

Gene expression profiles during C. neoformans infection; microarray analysis of mRNA levels was assessed at 0, 4, 8, 12, 16, 20, and 24 hours after C. neoformans incubation. Time points are represented by columns, and genes in rows. Red, green, and blue represent the higher, equal, and lower mRNA level relative to that of zero time point. A hierarchical clustering analysis of genes with expression levels that changed during C. neoformans and HBMEC interactions was performed. The distance among infectomic profiles of HBMEC is shown. Each lane represents a result form a gene chip. Genes with high intensity reading are shown in bright colors; genes with low intensity reading are in dim colors (grey) so they can be distinguished during analysis.