Metabolic Control Analysis: A Tool for Designing Strategies to Manipulate Metabolic Pathways

Figure 11

Modeled flux behavior when inhibiting pathway enzymes. The predicted flux when varying the enzyme activity was obtained using the kinetic model for Entamoeba histolytica glycolysis [142]. In this case, 100% enzyme activity is the enzyme activity present in amebal extracts, and 100% flux is the ethanol flux displayed by amoebae incubated with glucose. PPi-PFK, PPi-dependent phosphofructokinase; PPDK, pyruvate phosphate dikinase; PGAM, 2,3 bisphosphoglycerate independent 3-phosphoglycerate mutase.