Metabolic Control Analysis: A Tool for Designing Strategies to Manipulate Metabolic Pathways
Figure 2
Sulfur assimilation and glutathione and phytochelatins synthesis in plants ATPS, ATP sulfurylase; APS, adenosine phosphosulphate;
γ-ECS, γ-glutamyl cysteine synthetase; γ-EC, γ-glutamyl
cysteine; GS, glutathione synthetase; GSH, reduced glutathione; GSSG, oxidized
glutathione; GPx, GSH peroxidase; GR, GSH reductase; PCS, phytochelatin synthase;
PCs, phytochelatins; GT, GSH-S-transferases; Xe, xenobiotic; GS-Xe, glutathione-xenobiotic
complex. The reactions are not shown
stochiometrically. GR uses the cofactor
NADPH. The C-GSH complex formation (cadmium bis-glutathionate) is fast and spontaneous and
does not require enzyme catalysis. Modified
from [31].
