|
Enzyme | | Rat organ mitochondria | Specific inhibitor | Inhibition mechanism | Reference |
|
NADH-CoQ-oxidoreductase
(Site 1 of energy conservation or Complex I of respiratory chain) | 0.15 | Heart
(0.5 mM pyr + 0.2 M Ca2+) | Rotenone | Noncompetitive
tightly bound | [93]
|
0.26 | Heart
(10 mM pyr + 10 mM mal) | [95] |
0.31 | Kidney
(0.5 mM pyr + 0.2 M Ca2+) | [93] |
0.06 | Kidney (10 mM pyr + 10 mM mal) | [95] |
0.06–0.10 | Brain (0.05 mM pyr + 0.4 M Ca2+) | [91]
|
0.25 | Brain (10 mM pyr + 10 mM mal) | [95]
|
0 | Tumor (10 mM glut + 3 mM mal) | [96]
|
0.27 | Liver (10 mM pyr + 10 mM mal) | [95] |
0.13 | Skeletal muscle (10 mM pyr + 10 mM mal) | [95] |
|
CoQ.cytochrome
c oxidoreductase (Site 2 of energy conservation or Complex III of respiratory
chain) | 0.01 | Heart | Antimycin | Noncompetitive
tightly bound | [93]
|
0.19 | Heart | [95]
|
0.02 | Kidney | [95]
|
0.05–0.11 | Brain | [91]
|
0.02 | Brain | [95]
|
0 | Tumor | [96]
|
0.43 | Liver (5 mM Succ + 1 M Ca2+) | [94] |
0.07 | Liver | [95] |
0.22 | Skeletal muscle | [95] |
|
Cytochrome
c oxidase (Site 3 of energy conservation or Complex IV of respiratory chain) | 0.11 | Heart | Cyanide
or azide | Noncompetitive
simple | [93] |
0.13 | Heart | [95] |
0.04 | Kidney | [95] |
0.02–0.07 | Brain | [91] |
0.02 | Brain | [95] |
0.04 | Tumor | [96] |
0.23 | Liver | [94] |
0.03 | Liver | [95] |
0.20 | Skeletal
muscle | [95] |
|
ATP/ADP
transporter (adenine-nucleotides or ATP/ADP transporter, carrier or exchanger) | 0.24 | Heart | Carboxy-atractyloside (CAT) | Noncompetitive
tightly bound | [93] |
0.04 | Heart | [95]
|
0 | Kidney | [93] |
0.07 | Kidney | [95] |
0.08 | Brain
| [91] |
0.08 | Brain
| [95] |
0.60–0.70 | Tumor | [96] |
0.48 | Liver
| [93] |
0.01 | Liver
| [93] |
0.37 | Skeletal
muscle (10 mM Glut + 3 mM mal) | [97] |
0.08 | Skeletal
muscle | [95] |
ATP synthase | 0.34 | Heart | Oligomycin | Noncompetitive tightly bound | [93] |
0.12 | Heart | [95] |
0.32 | Kidney | [93] |
0.27 | Kidney | [95] |
0.09–0.20 | Brain | [91] |
0.26 | Brain | [95] |
0.28 | Tumor | [96] |
0.05 | Liver | [94] |
0.20 | Liver | [95] |
0.10 | Skeletal muscle | [97] |
0.10 | Skeletal muscle | [95] |
|
Pi transporter | 0.15 | Heart | Mersalyl | Noncompetitive simple | [93] |
0.14 | Heart | [95] |
0.43 | Kidney | [93] |
0.28 | Kidney | [95] |
0.13 | Brain | [91] |
0.26 | Brain | [95] |
0 | Tumor | [96] |
0.05–0.12 | Liver | [94] |
0.26 | Liver | [95] |
0.15 | Skeletal muscle | [97] |
0.08 | Skeletal muscle | [95] |
|
Pyruvate transporter | 0.15 | Heart | α-cyano-4-hydroxy-cinnamate | Noncompetitive simple | [95] |
0.03 | Kidney | [95] |
0.08 | Brain | [91] |
0.26 | Brain | [95] |
0.21 | Liver | [95] |
0.20 | Skeletal muscle | [95] |
|
Dicarboxylates transporter | 0.05–0.14 | Liver | Malate or butyl-malonate | Competitive simple | [94] |
|
External ATPase | 0.40 | Skeletal muscle | Purified ATPase addition | | [94] |
|