Biomarkers and Mechanisms of FANCD2 Function

Figure 1

Hypersensitivity of FANCD2-deficient human fibroblasts to DNA damage. (a) Clonogenic survival of cells with or without wild-type FANCD2 (PD20-wtD2 or PD20, resp.) after treatment with varying concentrations of MMC for one hour. (b) Analogously, clonogenic survival after exposure to hydrogen peroxide (H₂O₂) for two hours. Data represent logarithmic means +/− standard error based on four independent repeats.

(a)

(b)