Structure-Based Inhibitors Exhibit Differential Activities against Helicobacter pylori and Escherichia coli Undecaprenyl Pyrophosphate Synthases

Figure 2

The flow chart for computer screening of H. pylori UPPS inhibitors. The active zone for screening was focused on Asp13, an important amino acid residue for coordinating with catalytic Mg²⁺. In parentheses are the numbers of compounds. BTB06061 and HTS04781 are the final hits.