About this Journal Submit a Manuscript Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2008 (2008), Article ID 852571, 6 pages
http://dx.doi.org/10.1155/2008/852571
Research Article

The Activation of Macrophage and Upregulation of CD40 Costimulatory Molecule in Lipopolysaccharide-Induced Acute Lung Injury

1Department of Pulmonary Disease, Qilu Affiliated Hospital of Shandong University, Jinan, Shandong 250012, China
2Department of Biochemistry, School of Medicine, Shandong University, Jinan, Shandong 250012, China

Received 15 July 2007; Revised 2 February 2008; Accepted 12 March 2008

Academic Editor: Honnavara Ananthaswamy

Copyright © 2008 Liang Dong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. B. Ware and M. A. Matthay, “The acute respiratory distress syndrome,” The New England Journal of Medicine, vol. 342, no. 18, pp. 1334–1349, 2000. View at Publisher · View at Google Scholar
  2. M. J. Fenton and D. T. Golenbock, “LPS-binding proteins and receptors,” Journal of Leukocyte Biology, vol. 64, no. 1, pp. 25–32, 1998.
  3. A. Aderem and R. J. Ulevitch, “Toll-like receptors in the induction of the innate immune response,” Nature, vol. 406, no. 6797, pp. 782–787, 2000. View at Publisher · View at Google Scholar · View at PubMed
  4. K. Hoebe, X. Du, P. Georgel, et al., “Identification of Lps2 as a key transducer of MyD88-independent TIR signalling,” Nature, vol. 424, no. 6950, pp. 743–748, 2003. View at Publisher · View at Google Scholar · View at PubMed
  5. M. L. Lohmann-Matthes, C. Steinmuller, and G. Franke-Ullmann, “Pulmonary macrophages,” European Respiratory Journal, vol. 7, no. 9, pp. 1678–1689, 1994.
  6. K. Imaizumi, T. Kawabe, S. Ichiyama, et al., “Enhancement of tumoricidal activity of alveolar macrophages via CD40-CD40 ligand interaction,” American Journal of Physiology, vol. 277, no. 1, pp. L49–L57, 1999.
  7. J. A. Wiley, R. Geha, and A. G. Harmsen, “Exogenous CD40 ligand induces a pulmonary inflammation response,” Journal of Immunology, vol. 158, no. 6, pp. 2932–2938, 1997.
  8. C. van Kooten and J. Banchereau, “CD40-CD40 ligand,” Journal of Leukocyte Biology, vol. 67, no. 1, pp. 2–17, 2000.
  9. J. A. Nick, S. K. Young, K. K. Brown, et al., “Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation,” Journal of Immunology, vol. 164, no. 4, pp. 2151–2159, 2000.
  10. N. Hashimoto, T. Kawabe, K. Imaizumi, et al., “CD40 plays a crucial role in lipopolysaccharide-induced acute lung injury,” American Journal of Respiratory Cell and Molecular Biology, vol. 30, no. 6, pp. 808–815, 2004. View at Publisher · View at Google Scholar · View at PubMed
  11. A. Johansson, M. Lundborg, C. M. Skold, et al., “Functional, morphological, and phenotypical differences between rat alveolar and interstitial macrophages,” American Journal of Respiratory Cell and Molecular Biology, vol. 16, no. 5, pp. 582–588, 1997.
  12. D. R. Wesemann, H. Qin, N. Kokorina, and E. N. Benveniste, “TRADD interacts with STAT1-α and influences interferon-γ signaling,” Nature Immunology, vol. 5, no. 2, pp. 199–207, 2004. View at Publisher · View at Google Scholar · View at PubMed
  13. V. T. Nguyen and E. N. Benveniste, “Involvement of STAT-1 and ets family members in interferon-γ induction of CD40 transcription in microglia/macrophages,” Journal of Biological Chemistry, vol. 275, no. 31, pp. 23674–23684, 2000. View at Publisher · View at Google Scholar · View at PubMed
  14. D. R. Wesemann, Y. Dong, G. M. O'keefe, V. T. Nguyen, and E. N. Benveniste, “Suppressor of cytokine signaling 1 inhibits cytokine induction of CD40 expression in macrophages,” Journal of Immunology, vol. 169, no. 5, pp. 2354–2360, 2002.
  15. K. A. Fitzgerald, S. M. McWhirter, K. L. Faia, et al., “IKKε and TBK1 are essential components of the IRF3 signaling pathway,” Nature Immunology, vol. 4, no. 5, pp. 491–496, 2003. View at Publisher · View at Google Scholar · View at PubMed
  16. P. Tekamp-Olson, C. Gallegos, D. Bauer, et al., “Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues,” Journal of Experimental Medicine, vol. 172, no. 3, pp. 911–919, 1990. View at Publisher · View at Google Scholar
  17. J. N. Kline, “Eat dirt: CpG DNA and immunomodulation of asthma,” Proceedings of the American Thoracic Society, vol. 4, no. 3, pp. 283–288, 2007. View at Publisher · View at Google Scholar · View at PubMed
  18. R. Hammermann, J. Hirschmann, C. Hey, et al., “Cationic proteins inhibit L-arginine uptake in rat alveolar macrophages and tracheal epithelial cells. Implications for nitric oxide synthesis,” American Journal of Respiratory Cell and Molecular Biology, vol. 21, no. 2, pp. 155–162, 1999.
  19. Y. S. Lim, T.-B. Won, W. S. Shim, et al., “Induction of airway remodeling of nasal mucosa by repetitive allergen challenge in a murine model of allergic rhinitis,” Annals of Allergy, Asthma and Immunology, vol. 98, no. 1, pp. 22–31, 2007.
  20. J. W. Hollingsworth, G. S. Whitehead, K. L. Lin, et al., “TLR4 signaling attenuates ongoing allergic inflammation,” Journal of Immunology, vol. 176, no. 10, pp. 5856–5862, 2006.
  21. C. K. Wong, P. F. Y. Cheung, W. K. Ip, and C. W. K. Lam, “Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils,” American Journal of Respiratory Cell and Molecular Biology, vol. 37, no. 1, pp. 85–96, 2007. View at Publisher · View at Google Scholar · View at PubMed
  22. X. F. Lei, Y. Ohkawara, M. R. Stämpfli, et al., “Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice,” Journal of Clinical Investigation, vol. 101, no. 6, pp. 1342–1353, 1998. View at Publisher · View at Google Scholar · View at PubMed
  23. T. Agalioti, S. Lomvardas, B. Parekh, J. Yie, T. Maniatis, and D. Thanos, “Ordered recruitment of chromatin modifying and general transcription factors to the IFN-β promoter,” Cell, vol. 103, no. 4, pp. 667–678, 2000. View at Publisher · View at Google Scholar