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Journal of Biomedicine and Biotechnology
Volume 2009 (2009), Article ID 408794, 11 pages
Schwann Cells Overexpressing FGF-2 Alone or Combined with Manual Stimulation Do Not Promote Functional Recovery after Facial Nerve Injury
1Institute of Neuroanatomy, Hannover Medical School and Center for Systems Neuroscience (ZSN), 30625 Hannover, Germany
2Department of Otorhinolaryngology, University of Cologne, 50931 Cologne, Germany
3Department of Otorhinolaryngology, Friedrich-Schiller University Jena, 07740 Jena, Germany
4Department of Trauma, Hand and Reconstructive Surgery, University of Cologne, 50931, Germany
5Department of Orthopaedic Surgery, University of Cologne, 50931 Cologne, Germany
6School of Animal Biology, Western Australian Institute for Medical Research, The University of Western Australia, Crawley, Perth, WA 6009, Australia
7Department of Anatomy I, University of Cologne, 50931, Germany
Received 25 February 2009; Accepted 8 July 2009
Academic Editor: George Perry
Copyright © 2009 Kirsten Haastert et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- T. Hadlock, C. Sundback, D. Hunter, M. Cheney, and J. P. Vacanti, “A polymer foam conduit seeded with Schwann cells promotes guided peripheral nerve regeneration,” Tissue Engineering, vol. 6, no. 2, pp. 119–127, 2000.
- A. Mosahebi, P. Fuller, M. Wiberg, and G. Terenghi, “Effect of allogeneic schwann cell transplantation on peripheral nerve regeneration,” Experimental Neurology, vol. 173, no. 2, pp. 213–223, 2002.
- A. D. Ansselin, T. Fink, and D. F. Davey, “Peripheral nerve regeneration through nerve guides seeded with adult Schwann cells,” Neuropathology and Applied Neurobiology, vol. 23, no. 5, pp. 387–398, 1997.
- V. Guenard, P. Aebischer, and R. P. Bunge, “The astrocyte inhibition of peripheral nerve regeneration is reversed by Schwann cells,” Experimental Neurology, vol. 126, no. 1, pp. 44–60, 1994.
- N. Lago, C. Casas, E. M. Muir, J. Rogers, and X. Navarro, “Effects of Schwann cell transplants in an experimental nerve amputee model,” Restorative Neurology and Neuroscience, vol. 27, no. 1, pp. 67–78, 2009.
- Y.-S. Chen, C.-L. Hsieh, C.-C. Tsai, et al., “Peripheral nerve regeneration using silicone rubber chambers filled with collagen, laminin and fibronectin,” Biomaterials, vol. 21, no. 15, pp. 1541–1547, 2000.
- L. A. Pfister, M. Papaloizos, H. P. Merkle, and B. Gander, “Nerve conduits and growth factor delivery in peripheral nerve repair,” Journal of the Peripheral Nervous System, vol. 12, no. 2, pp. 65–82, 2007.
- A. M. Butt and J. Dinsdale, “Fibroblast growth factor 2 induces loss of adult oligodendrocytes and myelin in vivo,” Experimental Neurology, vol. 192, no. 1, pp. 125–133, 2005.
- R. Dono, “Fibroblast growth factors as regulators of central nervous system development and function,” American Journal of Physiology, vol. 284, no. 4, pp. R867–R881, 2003.
- C. Grothe and M. Timmer, “The physiological and pharmacological role of basic fibroblast growth factor in the dopaminergic nigrostriatal system,” Brain Research Reviews, vol. 54, no. 1, pp. 80–91, 2007.
- C. Grothe, K. Haastert, and J. Jungnickel, “Physiological function and putative therapeutic impact of the FGF-2 system in peripheral nerve regeneration-Lessons from in vivo studies in mice and rats,” Brain Research Reviews, vol. 51, no. 2, pp. 293–299, 2006.
- P. Aebischer, A. N. Salessiotis, and S. R. Winn, “Basic fibroblast growth factor released from synthetic guidance channels facilitates peripheral nerve regeneration across long nerve gaps,” Journal of Neuroscience Research, vol. 23, no. 3, pp. 282–289, 1989.
- N. Danielsen, B. Pettmann, H. L. Vahlsing, M. Manthorpe, and S. Varon, “Fibroblast growth factor effects on peripheral nerve regeneration in a silicone chamber model,” Journal of Neuroscience Research, vol. 20, no. 3, pp. 320–330, 1988.
- J. Jungnickel, K. Haase, J. Konitzer, M. Timmer, and C. Grothe, “Faster nerve regeneration after sciatic nerve injury in mice over-expressing basic fibroblast growth factor,” Journal of Neurobiology, vol. 66, no. 9, pp. 940–948, 2006.
- M. Timmer, S. Robben, F. Muller-Ostermeyer, G. Nikkhah, and C. Grothe, “Axonal regeneration across long gaps in silicone chambers filled with Schwann cells overexpressing high molecular weight FGF-2,” Cell Transplantation, vol. 12, no. 3, pp. 265–277, 2003.
- D. N. Angelov, O. Guntinas-Lichius, K. Wewetzer, W. F. Neiss, and M. Streppel, “Axonal branching and recovery of coordinated muscle activity after transection of the facial nerve in adult rats,” Advances in Anatomy Embryology and Cell Biology, vol. 180, pp. 1–130, 2005.
- D. N. Angelov, M. Ceynowa, O. Guntinas-Lichius, et al., “Mechanical stimulation of paralyzed vibrissal muscles following facial nerve injury in adult rat promotes full recovery of whisking,” Neurobiology of Disease, vol. 26, no. 1, pp. 229–242, 2007.
- K. Haastert, Z. Ying, C. Grothe, and F. Gomez-Pinilla, “The effects of FGF-2 gene therapy combined with voluntary exercise on axonal regeneration across peripheral nerve gaps,” Neuroscience Letters, vol. 443, no. 3, pp. 179–183, 2008.
- G. Keilhoff, F. Prätsch, G. Wolf, and H. Fansa, “Bridging extra large defects of peripheral nerves: possibilities and limitations of alternative biological grafts from acellular muscle and Schwann cells,” Tissue Engineering, vol. 11, no. 7-8, pp. 1004–1014, 2005.
- K. Haastert, E. Lipokatic, M. Fischer, M. Timmer, and C. Grothe, “Differentially promoted peripheral nerve regeneration by grafted Schwann cells over-expressing different FGF-2 isoforms,” Neurobiology of Disease, vol. 21, no. 1, pp. 138–153, 2006.
- S. Dohm, M. Streppel, O. Guntinas-Lichius, et al., “Local application of extracellular matrix proteins fails to reduce the number of axonal branches after varying reconstructive surgery on rat facial nerve,” Restorative Neurology and Neuroscience, vol. 16, no. 2, pp. 117–126, 2000.
- C. Guidry and F. Grinnell, “Heparin modulates the organization of hydrated collagen gels and inhibits gel contraction by fibroblasts,” Journal of Cell Biology, vol. 104, no. 4, pp. 1097–1103, 1987.
- C. Mauch, A. Hatamochi, K. Scharffetter, and T. Krieg, “Regulation of collagen synthesis in fibroblasts within a three-dimensional collagen gel,” Experimental Cell Research, vol. 178, no. 2, pp. 493–503, 1988.
- K. Haastert, J. Grosskreutz, M. Jaeckel, et al., “Rat embryonic motoneurons in long-term co-culture with Schwann cells—a system to investigate motoneuron diseases on a cellular level in vitro,” Journal of Neuroscience Methods, vol. 142, no. 2, pp. 275–284, 2005.
- C. Mauritz, C. Grothe, and K. Haastert, “Comparative study of cell culture and purification methods to obtain highly enriched cultures of proliferating adult rat Schwann cells,” Journal of Neuroscience Research, vol. 77, no. 3, pp. 453–461, 2004.
- F. Muller-Ostermeyer, P. Claus, and C. Grothe, “Distinctive effects of rat fibroblast growth factor-2 isoforms on PC12 and Schwann cells,” Growth Factors, vol. 19, no. 3, pp. 175–191, 2001.
- E. Verdu, X. Navarro, G. Gudino-Cabrera, et al., “Olfactory bulb ensheathing cells enhance peripheral nerve regeneration,” NeuroReport, vol. 10, no. 5, pp. 1097–1101, 1999.
- T. L. Tomov, O. Guntinas-Lichius, M. Grosheva, et al., “An example of neural plasticity evoked by putative behavioral demand and early use of vibrissal hairs after facial nerve transection,” Experimental Neurology, vol. 178, no. 2, pp. 207–218, 2002.
- H. J. Gundersen, “Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson,” Journal of Microscopy, vol. 143, pp. 3–45, 1986.
- A. S. Popratiloff, W. F. Neiss, E. Skouras, M. Streppel, O. Guntinas-Lichius, and D. N. Angelov, “Evaluation of muscle re-innervation employing pre- and post-axotomy injections of fluorescent retrograde tracers,” Brain Research Bulletin, vol. 54, no. 1, pp. 115–123, 2001.
- O. Guntinas-Lichius, A. Irintchev, M. Streppel, et al., “Factors limiting motor recovery after facial nerve transection in the rat: combined structural and functional analyses,” European Journal of Neuroscience, vol. 21, no. 2, pp. 391–402, 2005.
- J. G. Boyd and T. Gordon, “Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury,” Molecular Neurobiology, vol. 27, no. 3, pp. 277–323, 2003.
- M. Streppel, N. Azzolin, S. Dohm, et al., “Focal application of neutralizing antibodies to soluble neurotrophic factors reduces collateral axonal branching after peripheral nerve lesion,” European Journal of Neuroscience, vol. 15, no. 8, pp. 1327–1342, 2002.
- M. Greulich, “Anchoring the nasolabial fold,” in The Facial Palsies, C. H. Beurskens, R. S. van Gelder, P. G. Heymans, J. J. Manni, and J. P. A. Nicolai, Eds., pp. 235–243, Lemma Publishers, Utrecht, The Netherlands, 2005.
- O. Büngner, “Ueber die Degenerations- und Regenerationsvorgänge am Nerven nach Verletzungen,” Beiträge zur Pathologischen Anatomie, vol. 10, pp. 21–393, 1891.
- K. L. Golden, D. D. Pearse, B. Blits, et al., “Transduced Schwann cells promote axon growth and myelination after spinal cord injury,” Experimental Neurology, vol. 207, no. 2, pp. 203–217, 2007.
- G. Lundborg, “Alternatives to autologous nerve grafts,” Handchirurgie Mikrochirurgie Plastische Chirurgie, vol. 36, no. 1, pp. 1–7, 2004.
- C. E. Schmidt and J. B. Leach, “Neural tissue engineering: strategies for repair and regeneration,” Annual Review of Biomedical Engineering, vol. 5, pp. 293–347, 2003.
- C. T. Chalfoun, G. A. Wirth, and G. R. D. Evans, “Tissue engineered nerve constructs: where do we stand?” Journal of Cellular and Molecular Medicine, vol. 10, no. 2, pp. 309–317, 2006.
- K. Haastert and C. Grothe, “Gene therapy in peripheral nerve reconstruction approaches,” Current Gene Therapy, vol. 7, no. 3, pp. 221–228, 2007.
- J. Jungnickel, K. Haastert, M. Grzybek, et al., “Mice lacking basic fibroblast growth factor showed faster sensory recovery,” Experimental Neurology. In press.
- S. Pockett and J. R. Slack, “Source of the stimulus for nerve terminal sprouting in partially denervated muscle,” Neuroscience, vol. 7, no. 12, pp. 3173–3176, 1982.
- J. R. Slack and S. Pockett, “Terminal sprouting of motoneurones is a local response to a local stimulus,” Brain Research, vol. 217, no. 2, pp. 368–374, 1981.
- M. Sendtner, “Neurotrophic factors: effects in modulating properties of the neuromuscular endplate,” Cytokine and Growth Factor Reviews, vol. 9, no. 1, pp. 1–7, 1998.
- M. C. Brown and R. Ironton, “Motor neurone sprouting induced by prolonged tetrodotoxin block of nerve action potentials,” Nature, vol. 265, no. 5593, pp. 459–461, 1977.
- M. C. Brown, R. L. Holland, W. G. Hopkins, and R. J. Keynes, “An assessment of the spread of the signal for terminal sprouting within and between muscles,” Brain Research, vol. 210, no. 1-2, pp. 145–151, 1981.
- M. Grosheva, S. Arnhold, O. Guntinas-Lichius, et al., “Bone marrow-derived mesenchymal stem cell transplantation does not improve quality of muscle reinnervation or recovery of motor function after facial nerve transection in rats,” Biological Chemistry, vol. 389, no. 7, pp. 873–888, 2008.