Table 3: Quality of target muscle reinnervation. Reinnervation pattern of the levator labii superioris motor-end plates in intact rats, in rats after transection of the right facial nery followed by:- entubulation with collagen only, with collagen plus naive SC's, or with collagen plus genetically modified SC's. In group 6–9 entubulations were followed by manual mechanical stimulation (MS) of the vibrissal muscles. Motor endplates were classified a monoinnervated, polyinnervated, or noninnervated according to the number of beta-tubulin-immunoreactive axons that crossed th boundaries of the end-plate).

Group of animalsMonoinnervated motor end-plates (percent)Polyinnervated motor end-plates (percent)Noninnervated motor end-plates (percent)Total number of motor end-plates examined

1. Intact SD rats100 ± 0.00.00.01633 ± 143
2. Collagen only44 ± 8.0*46± 10*10 ± 3.0*1521 ± 162
3. Collagen +neonatal, naive SC's42 ± 8.0*49± 4.0*9.0 ± 2.0*1404 ± 108
4. Collagen + SC-FGF- 49 ± 7.0*45± 12*6.0 ± 1.0*1464 ± 159
5. Collagen + SC-FGF- 48 ± 16*47± 15*5.0 ± 4.0*1602 ± 258
6. Collagen only + MS47 ± 9.0*51± 10*2.0 ± 1.0*1362 ± 303
7. Collagen + neonatal, naive SC's + MS40 ± 8.0*48± 10*12±3.0*1512±102
8. Collagen + SC-FGF- + MS41 ± 3.0*49± 11*10±1.0*1413±141
9. Collagen + SC-FGF- + MS51 ± 8.0*42± 10*7 ± 3.0*1602 ± 150

*Significant differences of group mean values (ANOVA and post-hoc Tukey's test, from intact rats.