Molecularly Characterised Xenograft Tumour Mouse Models: Valuable Tools for Evaluation of New Therapeutic Strategies for Secondary Liver Cancers

Table 5

Relative differences in gene expression levels (n-fold) within tumour samples compared to derived cell cultures. n.d.: not determinable, Ct values obtained with cDNA derived either from cultured cells ($) or from both tumour samples and cells were below threshold (>39).

	AKH23 original cells	KFJ9 xenograft cells	KFJ10 xenograft cells
BCL2	0.37  ±  0.03	2.60  ±  0.64	35.13  ±  7.76
CCND1	0.40±0.09	0.85±0.33	0.50±0.08
CDC25B	0.89±0.14	1.18±0.11	0.50±0.08
CDKN1B	0.90±0.17	0.55±0.11	0.74±0.13
CTNNB1	0.54±0.12	0.93±0.2	1.03±0.08
EGFR	0.46±0.12	0.36  ±  0.09	0.78±0.07
ERBB2	0.73±0.16	1.24±0.15	0.68±0.1
ETV4	0.78±0.17	0.51±0.12	1.21±0.16
IL6	n.d.$	0.61±0.15	n.d.$
IL6R	5.88  ±  1.02	4.47  ±  0.65	2.27±0.33
IL8	0.54±0.08	0.89±0.41	0.92±0.03
KRAS2	1.08±0.16	0.50±0.11	0.73±0.24
MET	0.49±0.11	0.32  ±  0.07	0.42±0.06
MMP1	0.0027  ±  0.0006	n.d.	1.06±0.37
MMP11	10.47  ±  0.99	n.d.$	1.41±0.38
MYC	0.87±0.08	0.53±0.13	0.37  ±  0.05
PTGS2	0.71±0.22	n.d.	n.d.
SERPINB5	0.91±0.21	0.80±0.18	0.43±0.04
VEGFA	4.50  ±  0.92	0.96±0.17	1.83±0.21
VEGFC	n.d.$	n.d.	n.d.
WNT1	n.d.	n.d.	n.d.