The DNA colocalization happens when specific threshold values in are passed. A 3D phase diagram in the space of the molecular factors (MFs) concentration , the binding sites (BSs) number and the MF-BS interaction energy is shown. When the purple surface is crossed, a transition from a “Brownian Phase” (DNA loci diffuse as random walk polymers) to a “Colocalization Phase” (colocalized DNA loci) occurs. The yellow circles mark the measured transition points (at which the of DNA loci couples are paired); the purple surface was obtained by a power law fit (, , ).
