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Journal of Biomedicine and Biotechnology
Volume 2009 (2009), Article ID 571702, 10 pages
http://dx.doi.org/10.1155/2009/571702
Research Article

Poly(hydroxyalkanoates)-Based Polymeric Nanoparticles for Drug Delivery

Laboratory of Bioactive Polymeric Materials for Biomedical & Environmental Applications, UdR-INSTM, Department of Chemistry and Industrial Chemistry, University of Pisa, Via Risorgimento 35, 56126 Pisa, Italy

Received 13 February 2009; Accepted 29 June 2009

Academic Editor: Phillip E. Klebba

Copyright © 2009 Cesare Errico et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Poly (hydroxyalkanoates) (PHAs) have recently attracted a great deal of academic and industrial interest for their biodegradability and biocompatibility making them suitable for environmental and biomedical applications. Poly(3-hydroxybutyrate-) (PHB-) and Poly(DL-lactide-co-glycolide) (PLGA-) based nanoparticles were prepared using the dialysis method as yet unreported for the preparation of nanoparticles based on PHB. Processing conditions were varied in order to evaluate their influence on morphology, drug encapsulation, and size of nanoparticles. The relevant results obtained give a theoretical understanding of the phenomenon occurring during colloidal formation. The adopted procedure allows for a relatively small diameter and homogeneity in size distribution of the PHB nanoparticles to be obtained compared to other methods like the one based on solvent evaporation which leads to particles on microscale. The biocompatibility of PHB and relative nanoparticles was investigated and both exhibited very good cytocompatibility.