Pyrrolidine Dithiocarbamate Attenuates Paraquat-Induced Lung Injury in Rats
Figure 3
The lung ultrastructure of SD rats from groups of the control, PQ treatment, and PQPDTC treatment. Electron micrographs from control group (A3) showed a normal ultrastructure with the presence of pneumocytes type I and II. B3 (PQ group on the 3rd day) and C3 (PQ group on the 7th day) can be observed a type II pneumocyte with mitochondrial swelling (b), dilation of lamellar body (a), pneumocyte necrosis and alveolar collapse (↑). B4 (PQ+PDTC group on the 3rd day) and C4 (PQ+PDTC group on the 7th day) can be observed normal mitochondria and no alveolar collapse. D3 (PQ group on the 14th day) can be noticed the more numerous rough endroplasmic reticulum (RER) and ribosome (Ri) in fibroblast compared with D4 (PQ+PDTC group on the 14th day). showed E3 (PQ group on the 21st day) can be observed patchy collagen deposition within the expanded interstitium in some areas. E4 (PQ+PDTC group on the 21st day) can be observed a small quantity of collagen deposition.
