Table 2: Mean difference between the average distance from the best estimate of landmark position of automated and manual landmarking, standard deviation (SD) (expressed in mm), and results of 1-way ANOVA test. NS indicates no statistically significant difference and the number of asterisks (*) the level of significance.

Landmark coordinatesMean differenceStandard deviation (SD) -value -value (ANOVA)S

Nasion 0.217 0.4415.076.027*
0.483 0.44216.229.000**
A point 0.596 0.31246.633.000***
0.101 0.2820.484.489NS
Basion 0.181 0.1972.160.146NS
0.225 0.1122.538.115NS
Porion 0.003 0.1450.000.986NS
0.538 0.25724.051.000***
Pterygoid point 0.157 0.2961.786.185NS
0.022 0.0330.0298.863NS
B point 0.161 0.1306.846.011*
0.285 0.4022.762.101NS
Pogonion 0.038 0.3380.238.627NS
0.166 0.0331.385.243NS
Protuberance Menti 0.038 0.2260.314.577NS
0.245 0.1392.457.121NS
Upper incisor edge 0.172 0.0304.712.033*
0.100 0.3710.283.596NS
Lower incisor edge 0.226 0.2264.582.035*
0.283 0.0893.796.055NS

*Significance level .05. **Significance level .01. ***Significance level .001.