Research Article
A New Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Bisoprolol in Human Plasma Samples
Table 2
Evaluation of intraday precision and accuracy for bisoprolol spiked quality control samples.
| = 3 ng/mL | = 25 ng/mL | = 75 ng/mL | | (ng/mL) | % nominal | (ng/mL) | % nominal | (ng/mL) | % nominal |
| (1) | 2.912 | 98.391 | 22.524 | 91.263 | 69.203 | 93.468 | (2) | 3.003 | 101.439 | 24.862 | 100.737 | 68.525 | 92.552 | (3) | 3.262 | 110.192 | 23.762 | 96.281 | 66.781 | 90.196 | (4) | 2.829 | 95.568 | 25.189 | 102.062 | 76.691 | 103.580 | (5) | 3.018 | 101.960 | 21.739 | 88.085 | 65.844 | 88.931 | (6) | 2.854 | 96.431 | 21.371 | 86.593 | 74.009 | 99.958 | Mean | 2.980 | 100.664 | 23.241 | 94.170 | 70.176 | 94.781 | SD | 0.158 | | 1.610 | | 4.268 | | CV % | 5.296 | | 6.927 | | 6.082 | |
| | | Acceptance criteria | | |
| | | 67% Total QCs must be % nominal values | | | | | 50% QCs per level must be % nominal values | | | | | Mean % nominal % | | | | | CV (%) 15% | | |
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= theoretical concentration. = experimental concentration. SD = standard deviation. CV % = coefficient of variation
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