DNA Damage/Repair and Polymorphism of the hOGG1 Gene in Lymphocytes of AMD Patients

Table 3

The allele and genotype frequencies and odds ratio (OR) of the Ser326Cys polymorphism of the hOGG1 gene in AMD patients with inefficient repair of DNA lesions induced by hydrogen peroxide. Inefficient DNA repair occured when we did not observe a significant decrease in the extent of DNA damage after 120 minutes of repair incubation.

Genotype or allele	Controls (𝑛=17)		AMD patients (𝑛=21)		OR (95% PU)
	Number	Frequency	Number	Frequency
Ser/Ser	9	0.53	11	0.52	0.98 (0.27–3.52)
Ser/Cys	8	0.47	10	0.48	1.02 (0.28–3.68)
Cys/Cys	0	—	0	—	—
Ser	26	0.76	32	0.76	0.98 (0.34–2.85)
Cys	8	0.24	10	0.24	1.02 (0.35–2.94)