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Journal of Biomedicine and Biotechnology
Volume 2009 (2009), Article ID 876093, 6 pages
http://dx.doi.org/10.1155/2009/876093
Research Article

Characterization of Arterial Wave Reflection in Healthy Bonnet Macaques: Feasibility of Applanation Tonometry

1Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
2Primate Behavior Laboratory, Department of Psychiatry State University of New York , Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
3Department of Surgery, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA

Received 23 October 2008; Accepted 12 December 2008

Academic Editor: Mohamed Boutjdir

Copyright © 2009 Jason Lazar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nonhuman primates are commonly used in cardiovascular research. Increased arterial stiffness is a marker of subclinical atherosclerosis and higher CV risk. We determined the augmentation index (AI) using applanation tonometry in 61 healthy monkeys (59% female, age 1–25 years). Technically adequate studies were obtained in all subjects and required minutes. The brachial artery provided the highest yield (95%). AI was correlated with heart rate (HR) ( ), crown rump length (CRL) (r = 0.42, P = .001), and left ventricular (LV) mass determined using echocardiography ( ). On multivariate analysis, HR ( ) and CRL (P = .005) were independent predictors of AI ( ). Body Mass Index (BMI) and AI were independent predictors of higher LV mass on multivariate analysis ( and ). In conclusion, applanation tonometry is feasible for determining AI. Reference values are provided for AI in bonnet macaques, in whom higher AI is related to HR and CRL, and in turn contributes to higher LV mass.