Detection of EBV Infection and Gene Expression in Oral Cancer from Patients in Taiwan by Microarray Analysis
Table 4
Statistical association of viral gene expression patterns with cancer manifestations.
Analysis of Multiplicity
Gene Spot 57: P = .0702
Lesion
Single
Multiple
Total
Number Not Expressed
21 (44.68%)
16 (34.04%)
37 (78.72%)
Number Expressed
9 (19.15%)
1 (2.13%)
10 (21.28%)
Total
30 (63.83%)
17 (36.17%)
47 (100%)
Gene Spot 60: P = .0737
Lesion
Single
Multiple
Total
Number Not Expressed
24 (51.06%)
17 (36.17%)
41 (87.23%)
Number Expressed
6 (12.77%)
0 (0.00%)
6 (12.77%)
Total
30 (63.83%)
17 (36.17%)
47 (100%)
Analysis of Cancer Types
Gene Spot 61: P = .0265
Cancer types
Deep invasive
Exophytic
Ulcerative
Total
Number Not Expressed
4 (8.51%)
6 (12.77%)
1 (2.13%)
11 (23.40%)
Number Expressed
3 (6.38%)
18 (38.30%)
15 (31.91%)
36 (76.60%)
Total
7 (14.89%)
24 (51.06%)
16 (34.04%)
47 (100%)
Gene Spot 68: P = .0141
Cancer types
Deep invasive
Exophytic
Ulcerative
Total
Number Not Expressed
7 (14.89%)
15 (31.91%)
6 (12.77%)
28 (59.57%)
Number Expressed
0 (0.00%)
9 (19.15%)
10 (21.28%)
19 (40.43%)
Total
7 (14.89%)
24 (51.06%)
16 (34.04%)
47 (100%)
The clinical manifestations of oral cancer (Table 1) were correlated with the chip-hybridization results of EBV-positive samples (Figure 2). The statistical analysis method used in the present study is Fisher’s Exact Test and two-tailed.
