Gene Expression Analysis of an EGFR Indirectly Related Pathway Identified PTEN and MMP9 as Reliable Diagnostic Markers for Human Glial Tumor Specimens
Figure 3
Dendrogram comparing PTEN and MMP9 absolute quantitative expression. Absolute quantifications are expressed in femtograms, as reported in Materials and Methods. WHO grades of malignancy (III, IV) and healthy brain control (C) specimens are indicated. Glioblastoma multiforme subgroups IV-a, including the majority of glioblastoma specimens, and IV-b, described in Results, are highlighted. The box (*) indicates subgrouping of patients sharing similar tumor anatomical localization (i.e., temporal). Subgroups IV-a and IV-b have a different and significant distribution of age-class III patients (61 years, Anova-one way).
