Cytotoxic T Cells in H. pylori-Related Gastric Autoimmunity and Gastric Lymphoma

Table 1

Immunodeficient mouse strains that develop spontaneous or induced lymphoma.

Strain	Description	Phenotype	Ref
Perforin −/−	Lack perforin	Mice develop B cell lymphomas at 14–21 months	[92]
IFNg −/−	Lack IFN-𝛾	Mice develop predominantly T cell lymphomas at 13–19 months	[93]
Perforin −/−IFNg −/−	Lack perforin and IFN-𝛾	Mice develop B cell lymphomas similar to those observed in perforin-deficient mice, but with earlier onset and increased frequency	[93]
Perforin −/−B2m −/−	Lack perforin and MHC I	Mice develop B cell lymphomas similar to those observed in perforin-deficient mice, but with earlier onset and increased frequency	[94]
Trail −/−	Lack trail	25% of mice develop lymphomas later in life (> 400 days)	[95]
IFNg −/−	Lack IFN-𝛾	Increased susceptibility to N-methyl-N-nitrosurea-induced lymphomas	[97, 99]
IL12p35 −/−	Lack IL-12	Increased susceptibility to N-methyl-N-nitrosurea-induced lymphomas	[97]
P53 +/−Perforin −/−	Heterozygous for p53 and lack perforin	Accelerated onset of B cell lymphomas	[92]
IFNg −/−HTLVTax transgenic	Lack IFN-𝛾 and transgenic for Tax	Accelerated onset of lymphomas or leukemia	[98]