Table 1: Immunodeficient mouse strains that develop spontaneous or induced lymphoma.

StrainDescriptionPhenotypeRef

Perforin / Lack perforinMice develop B cell lymphomas at 14–21 months[92]
IFNg / Lack I F N - 𝛾 Mice develop predominantly T cell lymphomas at 13–19 months [93]
Perforin / IFNg / Lack perforin and I F N - 𝛾 Mice develop B cell lymphomas similar to those observed in perforin-deficient mice, but with earlier onset and increased frequency [93]
Perforin / B2m / Lack perforin and MHC IMice develop B cell lymphomas similar to those observed in perforin-deficient mice, but with earlier onset and increased frequency [94]
Trail / Lack trail25% of mice develop lymphomas later in life ( >  400 days) [95]
IFNg / Lack I F N - 𝛾 Increased susceptibility to N-methyl-N-nitrosurea-induced lymphomas[97, 99]
IL12p35 / Lack I L - 1 2 Increased susceptibility to N-methyl-N-nitrosurea-induced lymphomas[97]
P53 + / Perforin / Heterozygous for p53 and lack perforinAccelerated onset of B cell lymphomas[92]
IFNg / HTLVTax transgenic Lack I F N - 𝛾  and transgenic for TaxAccelerated onset of lymphomas or leukemia[98]