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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 141657, 6 pages
http://dx.doi.org/10.1155/2010/141657
Review Article

Viral Vaccines and CTL Response

Department of Microbiology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA

Received 7 December 2009; Accepted 24 February 2010

Academic Editor: Hanchun Yang

Copyright © 2010 Stacie N. Woolard and Uday Kumaraguru. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Immune induction by successful vaccine formulations seems to involve stimulation of both humoral and cellular arms of immunity. Nevertheless, CD8+ CTLs are of critical relevance in the context of intracellular infection and tumor for many reasons. The task of exerting antipathogen activity by CD8+ T cells, which principally function to control and eradicate intracellular pathogens, is enabled by constitutive expression of MHC class-I molecules on all tissue types. CTL induction offers hope for vaccines against pathogens that are resistant to neutralizing activity. This review discusses the mechanism of immune induction by some successful vaccines and based on the accrued evidence suggests ideas for improved design of CTL-inducing vaccines.