Review Article
Viral Vaccines and CTL Response
Table 1
Factors that makes control by vaccines problematic [
6–
9].
| (i) | Antigenic plasticity—all RNA viruses | (ii) | Possession of immune evasion maneuvers, for example, targeting antigen-presenting cells and lymphocytes | | (iii) | Persistence and latency | (iv) | Entrance and major replication at mucosal surfaces | (v) | Poor or retarded immune induction | (vi) | Resistance to neutralization by antibody | (vii) | Immunity solely dependent on T cells |
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