Review Article
Viral Vaccines and CTL Response
Table 4
Hepatitis C Immune Escape Tricks [
8,
9,
23].
| | (i) | Viral sequence mutations allow escape of both Ab and T cell recognition (NB high replication rate) | | | (ii) | HCV core protein binds a complement protein that results in downregulation of IL-12 production and affects T cell induction | | | | (iii) | Express a protease which interrupts induction of interferon a/b | | | (iv) | Incomplete differentiation of HCV-specific T cells may occur (like chronic memory cells) | | | (v) | Induction of IL-10-producing Treg cells | | (vi) | Also an involvement of CD4 CD25 natural Tregs |
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