Review Article

Shaping Successful and Unsuccessful CD8 T Cell Responses Following Infection

Figure 4

Regulation of transcription factors that impart CD8 T cell fate and function by external signaling. Black arrows indicate induction; red dots represent suppression. Blimp-1 and Bcl-6 are mutually repressive in CD8 T cells. IL-21 induces both Blimp-1 and Bcl-6 in B cells and is capable of inducing Blimp-1 in CD8 T cells. Induction of Bcl-6 in response to IL-21 in CD8 T cells has yet to be evaluated, as indicated by the dashed line with the question mark.
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