Figure 2: Immunohistochemical demonstration of BrdU-containing nuclei of S-phase cells in OSOM of control kidneys (a) or after reperfusion (b, c, d). S3 tubules of controls are characterized by a very low cell turn-over (a). In contrast cell proliferation increases dramatically in injured tubules two days after ischemia (c). The density of interstitial BrdU-positive cells is high in the periphery of necrotic tubules (NT) 1 and 2 days after ischemia (b, c) but appear similar to controls 2 week after ischemia (d). Scale bar. : (a, b); : (c, d).