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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 193259, 10 pages
http://dx.doi.org/10.1155/2010/193259
Research Article

Expression of Nestin, Vimentin, and NCAM by Renal Interstitial Cells after Ischemic Tubular Injury

1Laboratory of Histology, Faculty of Medicine and Pharmacy, University of Mons, Avenue du Champ de Mars, 6 (Pentagone) 1B, 7000 Mons, Belgium
2Laboratory of Physiology and Pharmacology, Faculty of Medicine and Pharmacy, University of Mons, 7000 Mons, Belgium
3Laboratory of General Physiology, Faculty of Medicine, Facultés Universitaires Notre-Dame de la Paix, 5000 Namur, Belgium

Received 1 December 2009; Revised 12 March 2010; Accepted 13 April 2010

Academic Editor: Anton M. Jetten

Copyright © 2010 David Vansthertem et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Q. Al-Awqati and J. A. Oliver, “Stem cells in the kidney,” Kidney International, vol. 61, no. 2, pp. 387–395, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. B. D. Humphreys, J. D. Duffield, and J. V. Bonventre, “Renal stem cells in recovery from acute kidney injury,” Minerva Urologica e Nefrologica, vol. 58, no. 4, pp. 329–337, 2006. View at Scopus
  3. J. V. Bonventre, “Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure,” Journal of the American Society of Nephrology, vol. 14, no. 1, pp. S55–S61, 2003. View at Scopus
  4. F. Lin, K. Cordes, L. Li et al., “Hematopoietic stem cells contribute to the regeneration of renal tubules after renal ischemia-reperfusion injury in mice,” Journal of the American Society of Nephrology, vol. 14, no. 5, pp. 1188–1199, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Krause and L. G. Cantley, “Bone marrow plasticity revisited: protection or differentiation in the kidney tubule?” Journal of Clinical Investigation, vol. 115, no. 7, pp. 1705–1708, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Li, P. Truong, P. Igarashi, and F. Lin, “Renal and bone marrow cells fuse after renal ischemic injury,” Journal of the American Society of Nephrology, vol. 18, no. 12, pp. 3067–3077, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Poulsom, M. R. Alison, T. Cook et al., “Bone marrow stem cells contribute to healing of the kidney,” Journal of the American Society of Nephrology, vol. 14, supplement 1, pp. S48–S54, 2003. View at Scopus
  8. D. Vansthertem, N. Caron, A.-E. Declèves et al., “Label-retaining cells and tubular regeneration in postischaemic kidney,” Nephrology Dialysis Transplantation, vol. 23, no. 12, pp. 3786–3797, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. G. J. Becker and T. D. Hewitson, “The interstitium in renal disease,” Journal of Internal Medicine, vol. 242, no. 2, pp. 93–97, 1997. View at Scopus
  10. B. Kaissling, I. Hegyi, J. Loffing, and M. Le Hir, “Morphology of interstitial cells in the healthy kidney,” Anatomy and Embryology, vol. 193, no. 4, pp. 303–318, 1996. View at Scopus
  11. G. Toubeau, D. Nonclercq, J. Zanen, G. Laurent, P. Schaudies, and J. A. Heuson-Stiennon, “Renal tissue expression of epidermal growth factor receptor after ischemic tubular injury: an immunohistochemical study,” Experimental Nephrology, vol. 2, no. 4, pp. 229–239, 1994.
  12. R. Witzgall, D. Brown, C. Schwarz, and J. V. Bonventre, “Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells,” Journal of Clinical Investigation, vol. 93, no. 5, pp. 2175–2188, 1994. View at Scopus
  13. Y.-H. Chou, S. Khuon, H. Herrmann, and R. D. Goldman, “Nestin promotes the phosphorylation-dependent disassembly of vimentin intermediate filaments during mitosis,” Molecular Biology of the Cell, vol. 14, no. 4, pp. 1468–1478, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Wiese, A. Rolletschek, G. Kania et al., “Nestin expression—a property of multi-lineage progenitor cells?” Cellular and Molecular Life Sciences, vol. 61, no. 19-20, pp. 2510–2522, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Chen, S. Boyle, M. Zhao et al., “Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes,” Journal of the American Society of Nephrology, vol. 17, no. 5, pp. 1283–1291, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Abbate, D. Brown, and J. V. Bonventre, “Expression of NCAM recapitulates tubulogenic development in kidneys recovering from acute ischemia,” American Journal of Physiology, vol. 277, no. 3, pp. F454–F463, 1999. View at Scopus
  17. R. P. Schaudies, D. Nonclercq, L. Nelson et al., “Endogenous EGF as a potential renotrophic factor in ischemia-induced acute renal failure,” American Journal of Physiology, vol. 265, no. 3, pp. F425–F434, 1993. View at Scopus
  18. D. Nonclercq, V. Liénard, J. Zanen, G. Laurent, and G. Toubeau, “Phenotypic variations and dynamic topography of transformed cells in an experimental model of diethylstilbestrol-induced renal tumour in male Syrian hamster,” Histochemical Journal, vol. 34, no. 10, pp. 487–497, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. M. B. Herrera, B. Bussolati, S. Bruno et al., “Exogenous mesenchymal stem cells localize to the kidney by means of CD44 following acute tubular injury,” Kidney International, vol. 72, no. 4, pp. 430–441, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Daniel, H. Albrecht, A. Lüdke, and C. Hugo, “Nestin expression in repopulating mesangial cells promotes their proliferation,” Laboratory Investigation, vol. 88, no. 4, pp. 387–397, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Michalczyk and M. Ziman, “Nestin structure and predicted function in cellular cytoskeletal organisation,” Histology and Histopathology, vol. 20, no. 2, pp. 665–671, 2005. View at Scopus
  22. C. Francavilla, S. Loeffler, D. Piccini, A. Kren, G. Christofori, and U. Cavallaro, “Neural cell adhesion molecule regulates the cellular response to fibroblast growth factor,” Journal of Cell Science, vol. 120, no. 24, pp. 4388–4394, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Turner and R. Grose, “Fibroblast growth factor signalling: from development to cancer,” Nature Reviews Cancer, vol. 10, no. 2, pp. 116–129, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. F. Strutz and M. Zeisberg, “Renal fibroblasts and myofibroblasts in chronic kidney disease,” Journal of the American Society of Nephrology, vol. 17, no. 11, pp. 2992–2998, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Brezis and S. Rosen, “Hypoxia of the renal medulla—its implications for disease,” The New England Journal of Medicine, vol. 332, no. 10, pp. 647–655, 1995. View at Publisher · View at Google Scholar · View at Scopus
  26. K.-U. Eckardt, C. Rosenberger, J. S. Jürgensen, and M. S. Wiesener, “Role of hypoxia in the pathogenesis of renal disease,” Blood Purification, vol. 21, no. 3, pp. 253–257, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Sakairi, K. Hiromura, S. Yamashita et al., “Nestin expression in the kidney with an obstructed ureter,” Kidney International, vol. 72, no. 3, pp. 307–318, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. J.-L. Bascands, J. Klein, and J. P. Schanstra, “A nest in renal fibrosis?” Kidney International, vol. 72, no. 3, pp. 242–244, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Villanueva, C. Céspedes, and C. P. Vio, “Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins,” American Journal of Physiology, vol. 290, no. 4, pp. R861–R870, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. T. A. Wynn, “Cellular and molecular mechanisms of fibrosis,” Journal of Pathology, vol. 214, no. 2, pp. 199–210, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Guarino, A. Tosoni, and M. Nebuloni, “Direct contribution of epithelium to organ fibrosis: epithelial-mesenchymal transition,” Human Pathology, vol. 40, no. 10, pp. 1365–1376, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. V. Paunescu, F. M. Bojin, C. A. Tatu, et al., “Tumor-associated fibroblasts 4 and mesenchymal stem cells: more similarities than differences,” Journal of Cellular and Molecular Medicine. In press.
  33. G. Stokman, J. C. Leemans, I. Stroo et al., “Enhanced mobilization of bone marrow cells does not ameliorate renal fibrosis,” Nephrology Dialysis Transplantation, vol. 23, no. 2, pp. 483–491, 2008. View at Publisher · View at Google Scholar · View at Scopus