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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 202397, 12 pages
http://dx.doi.org/10.1155/2010/202397
Research Article

Activation-Induced T Helper Cell Death Contributes to Th1/Th2 Polarization following Murine Schistosoma japonicum Infection

1Department of Pathogen Biology and Immunology, Department of Pharmacology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu 210029, China
2Department of Clinical Laboratories, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China

Received 29 July 2009; Accepted 15 October 2009

Academic Editor: Luis I. Terrazas

Copyright © 2010 Xinyu Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Infante-Duarte, “Th1/Th2 balance in infection,” Springer Seminars in Immunopathology, vol. 21, no. 3, pp. 317–338, 1999. View at Publisher · View at Google Scholar · View at Scopus
  2. R. M. Anthony, L. I. Rutitzky, J. F. Urban, M. J. Stadecker, and W. C. Gause, “Protective immune mechanisms in helminth infection,” Nature Reviews Immunology, vol. 7, no. 12, pp. 975–987, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. A. S. MacDonald, M. I. Araujo, and E. J. Pearce, “Immunology of parasitic helminth infections,” Infection and Immunity, vol. 70, no. 2, pp. 427–433, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. P. R. Rogers and M. Croft, “Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance,” Journal of Immunology, vol. 163, no. 3, pp. 1205–1213, 1999. View at Scopus
  5. M. Y. Balkhi, V. K. Latchumanan, B. Singh, P. Sharma, and K. Natarajan, “Cross-regulation of CD86 by CD80 differentially regulates T helper responses from Mycobacterium tuberculosis secretory antigen-activated dendritic cell subsets,” Journal of Leukocyte Biology, vol. 75, no. 5, pp. 874–883, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. I. Gutcher and B. Becher, “APC-derived cytokines and T cell polarization in autoimmune inflammation,” Journal of Clinical Investigation, vol. 117, no. 5, pp. 1119–1127, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Wiethe, A. Debus, M. Mohrs, A. Steinkasserer, M. Lutz, and A. Gessner, “Dendritic cell differentiation state and their interaction with NKT cells determine Th1/Th2 differentiation in the murine model of Leishmania major infection,” Journal of Immunology, vol. 180, no. 7, pp. 4371–4381, 2008. View at Scopus
  8. J. Zhu and W. E. Paul, “CD4 T cells: fates, functions, and faults,” Blood, vol. 112, no. 5, pp. 1557–1569, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Baumann, A. Krueger, S. Kirchhoff, and P. H. Krammer, “Regulation of T cell apoptosis during the immune response,” Current Molecular Medicine, vol. 2, no. 3, pp. 257–272, 2002. View at Scopus
  10. P. H. Krammer, R. Arnold, and I. N. Lavrik, “Life and death in peripheral T cells,” Nature Reviews Immunology, vol. 7, no. 7, pp. 532–542, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. T. A. Wynn, R. W. Thompson, A. W. Cheever, and M. M. Mentink-Kane, “Immunopathogenesis of schistosomiasis,” Immunological Reviews, vol. 201, pp. 156–167, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. G. N. Gobert, M. Chai, and D. P. McManus, “Biology of the schistosome lung-stage schistosomulum,” Parasitology, vol. 134, no. 4, pp. 453–460, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. E. J. Pearce and A. S. MacDonald, “The immunobiology of schistosomiasis,” Nature Reviews Immunology, vol. 2, no. 7, pp. 499–511, 2002. View at Scopus
  14. E. J. Pearce, “Priming of the immune response by schistosome eggs,” Parasite Immunology, vol. 27, no. 7-8, pp. 265–270, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. S. K. Lundy, S. P. Lerman, and D. L. Boros, “Soluble egg antigen-stimulated T helper lymphocyte apoptosis and evidence for cell death mediated by FasL+ T and B cells during murine Schistosoma mansoni infection,” Infection and Immunity, vol. 69, no. 1, pp. 271–280, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. S. K. Lundy and D. L. Boros, “Fas ligand-expressing B-1a lymphocytes mediate CD4+-T-cell apoptosis during schistosomal infection: induction by interleukin 4 (IL-4) and IL-10,” Infection and Immunity, vol. 70, no. 2, pp. 812–819, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. P. G. Fallon, P. Smith, and D. W. Dunne, “Type 1 and type 2 cytokine-producing mouse CD4+ and CD8+ T cells in acute Schistosoma mansoni infection,” European Journal of Immunology, vol. 28, no. 4, pp. 1408–1416, 1998. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Chen and D. L. Boros, “Identification of the immunodominant T cell epitope of p38, a major egg antigen, and characterization of the epitope-specific th responsiveness during murine schistosomiasis mansoni,” Journal of Immunology, vol. 160, no. 11, pp. 5420–5427, 1998. View at Scopus
  19. I. R. Caldas, A. C. Campi-Azevedo, L. F. A. Oliveira, A. M. S. Silveira, R. C. Oliveira, and G. Gazzinelli, “Human schistosomiasis mansoni: immune responses during acute and chronic phases of the infection,” Acta Tropica, vol. 108, no. 2-3, pp. 109–117, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. M. S. Wilson, M. M. Mentink-Kane, J. T. Pesce, T. R. Ramalingam, R. Thompson, and T. A. Wynn, “Immunopathology of schistosomiasis,” Immunology and Cell Biology, vol. 85, no. 2, pp. 148–154, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. A. S. Varadhachary, S. N. Perdow, C. Hu, M. Ramanarayanan, and P. Salgame, “Differential ability of T cell subsets to undergo activation-induced cell death,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 11, pp. 5778–5783, 1997. View at Publisher · View at Google Scholar · View at Scopus
  22. X. R. Zhang, L. Y. Zhang, S. Devadas, L. Li, A. D. Keegan, and Y. F. Shi, “Reciprocal expression of TRAIL and CD95L in Th1 and Th2 cells: role of apoptosis in T helper subset differentiation,” Cell Death and Differentiation, vol. 10, no. 2, pp. 203–210, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Zheng and M. Lenardo, “T helper 2 cells' preferred way to die,” Immunity, vol. 25, no. 2, pp. 187–188, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. X. Zhang, T. Brunner, L. Carter, et al., “Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis,” Journal of Experimental Medicine, vol. 185, no. 10, pp. 1837–1849, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Devadas, J. Das, C. Liu, et al., “Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cells,” Immunity, vol. 25, no. 2, pp. 237–247, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. A. S. Kashyap, K. P. Anand, and S. Kashyap, “Artesunate for malaria,” The New England Journal of Medicine, vol. 359, no. 3, pp. 314–315, 2008. View at Scopus
  27. P. J. Rosenthal, “Artesunate for the treatment of severe falciparum malaria,” The New England Journal of Medicine, vol. 358, no. 17, pp. 1829–1836, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Shaohong, T. Kumagai, A. Qinghua, et al., “Evaluation of the anthelmintic effects of artesunate against experimental Schistosoma mansoni infection in mice using different treatment protocols,” Parasitology International, vol. 55, no. 1, pp. 63–68, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. W. Jiraungkoorskul, S. Sahaphong, P. Sobhon, S. Riengrojpitak, and N. Kangwanrangsan, “Schistosoma mekongi: the in vitro effect of praziquantel and artesunate on the adult fluke,” Experimental Parasitology, vol. 113, no. 1, pp. 16–23, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. W. Ru, Y. Li, J. Dai, et al., “Studies on effect of artesunate against Schistosoma japonicum—I: susceptibility of different developed stages of worms in mice to artesunate,” Chinese Journal of Schistosomiasis Control, vol. 18, pp. 161–164, 2006.
  31. A. Krueger, S. C. Fas, S. Baumann, and P. H. Krammer, “The role of CD95 in the regulation of peripheral T-cell apoptosis,” Immunological Reviews, vol. 193, pp. 58–69, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Lieberman, “The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal,” Nature Reviews Immunology, vol. 3, no. 5, pp. 361–370, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. D. A. Thomas, C. Du, M. Xu, X. Wang, and T. J. Ley, “DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis,” Immunity, vol. 12, no. 6, pp. 621–632, 2000. View at Scopus
  34. J. A. Trapani, D. A. Jans, P. J. Jans, M. J. Smyth, K. A. Browne, and V. R. Sutton, “Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent,” Journal of Biological Chemistry, vol. 273, no. 43, pp. 27934–27938, 1998. View at Publisher · View at Google Scholar · View at Scopus