Physiological and Histopathological Investigations on the Effects of 𝛼-Lipoic Acid in Rats Exposed to Malathion

Table 1

Changes in values of serum GOT, GPT, ALP, ACP, total protein, total albumin, creatinine, urea, and uric acid in rats treated with malathion, malathion plus 𝛼-lipoic acid, and 𝛼-lipoic acid. Tabulated values are means of ten determinations ± standard deviation (SD).

Parameters	Treatment
	Control	Malathion	Malathion +𝛼-Lipoic acid	𝛼-lipoic acid
GOT (UL^−1)	61.80 ± 3.29	189.40 ± 13.62^a,b	115.30 ± 5.8^a	56.70 ± 6.52
GPT (UL^−1)	39.50 ± 3.17	112.70 ± 9.99^a,b	64.30 ± 7.84^a	38.20 ± 2.52
ALP (UL^−1)	324.40 ± 10.86	632.70 ± 29.89^a,b	395.30 ± 37.05^a	339.20 ± 20.61
ACP (UL^−1)	109.80 ± 9.25	166.40 ± 27.69^a,b	139.30 ± 17.17^a	114.20 ± 13.58
Total protein (g 100 mL^−1)	6.75 ± 0.28	5.51 ± 0.30^a,b	6.64 ± 0.38	6.73 ± 0.28
Total albumin (g 100 mL^−1)	3.18 ± 0.19	2.86 ± 0.20^a,b	3.13 ± 0.23	3.24 ± 0.25
Creatinine (mg 100 mL^−1)	0.67 ± 0.05	1.16 ± 0.24^a,b	0.82 ± 0.11^a	0.70 ± 0.08
Urea (mg 100 mL^−1)	23.56 ± 1.77	30.12 ± 2.45^a,b	25.28 ± 1.92	22.74 ± 2.04
Uric acid (mg 100 mL^−1)	3.71 ± 0.27	4.90 ± 0.47^a,b	4.01 ± 0.36	3.86 ± 0.26

a: Indicates a significant difference between control and treated groups.
b: Indicates a significant difference between the group treated with malathion and groups treated with malathion plus 𝛼-lipoic acid and 𝛼-lipoic acid.