Association of TNFAIP3 Polymorphism with Susceptibility to Systemic Lupus Erythematosus in a Japanese Population

Table 1

Association of the TNFAIP3 region SNPs with SLE in a Japanese population.

				Allele 𝑛 (%)	versus controls (𝑛=444)				versus JSNP controls (𝑛=934)
	Genotype 𝑛 (%)				Allelic association		Recessive model^#		Allelic association		Recessive model^#
					𝑃	OR (95%CI)	𝑃	OR (95%CI)	𝑃	OR (95%CI)	𝑃	OR (95%CI)
rs13192841	A/A	G/A	G/G	A
SLE	5(1.6)	64(20.1)	249(78.3)	74(11.6)	.43	1.14 (0.82–1.58)	.29	2.35 (0.58–9.51)	.45	1.12 (0.84–1.48)	.36	1.64 (0.55–4.88)
controls	3(0.7)	86(19.4)	355(80.0)	92(10.4)		reference		reference
JSNP controls^∗	9(1.0)	179(19.2)	745(79.8)	197(10.6)						reference		reference
rs2230926	G/G	T/G	T/T	G
SLE	6(1.9)	56(17.6)	256(80.5)	68(10.7)	.033	1.47 (1.03–2.09)	.023	8.52 (1.45–50.1)	6.2×10^−4	1.17 (1.26–2.33)	.049	2.97 (1.00–8.82)
controls	1(0.2)	65(14.6)	378(85.1)	67(7.5)		reference		reference
JSNP controls^∗	6(0.6)	110(11.8)	818(87.6)	122(6.5)						reference		reference
rs6922466	G/G	A/G	A/A	G
SLE	12(3.8)	86(27.0)	220(69.2)	110(17.3)	.80	0.97 (0.74–1.26)	.97	0.99 (0.46–2.09)	.20	0.86 (0.68–1.09)	.40	0.76 (0.40–1.45)
controls	17(3.8)	124(27.9)	303(68.2)	158(17.8)		reference		reference
JSNP controls^∗	46(4.9)	274(29.3)	614(65.7)	366(19.6)						reference		reference

OR: odds ratio, 95%CI: confidence interval.
^∗Genotype data of healthy Japanese individuals obtained from JSNP DATABASE.
^#Recessive model for the minor allele.