Research Article

Trypsin Isoinhibitors with Antiproliferative Activity toward Leukemia Cells from Phaseolus vulgaris cv “White Cloud Bean”

Table 4

Inhibition rate (%) of white cloud bean trypsin inhibitors on L1210 cells, MBL2 cells, and HIV-1 reverse transcriptase (RT). Results are presented as mean ± SD ( 𝑛 = 3 ).

Dose ( 𝜇 M)Trypsin inhibitor (SP3SU2)trypsin inhibitor (SP2SU2)
L1210 cellsMBL2 cellsHIV-1 RTL1210 cellsMBL2 cellsHIV-1 RT

100 9 3 . 2 ± 5 . 7 a 4 . 8 ± 1 . 5 3 . 8 ± 0 . 6 8 8 . 1 ± 7 . 2 a 5 . 0 ± 1 . 4 5 . 0 ± 0 . 8
50 7 9 . 3 ± 5 . 0 b 2 . 7 ± 0 . 7 5 . 3 ± 1 . 1 6 8 . 6 ± 5 . 3 b 4 . 1 ± 0 . 8 4 . 7 ± 1 . 0
25 5 6 . 0 ± 3 . 8 c 3 . 4 ± 1 . 2 3 . 4 ± 1 . 3 4 4 . 9 ± 3 . 4 c 3 . 5 ± 1 . 5 4 . 5 ± 1 . 3
12.5 2 4 . 7 ± 3 . 1 d 4 . 2 ± 0 . 9 4 . 0 ± 1 . 8 2 1 . 3 ± 2 . 2 d 4 . 3 ± 1 . 0 3 . 1 ± 0 . 6

Different alphabets (e.g., a, b, c, and d) indicate statistically significant difference ( 𝑃 < . 0 5 ) when data were analyzed by analysis of variance followed by Duncan’s multiple range test.