Comparative Pathogenesis and Systems Biology for Biodefense Virus Vaccine Development
Figure 1
A generic example of analysis using k-means clustering. Data, such as from an mRNA expression microarray following mock, virulent, and attenuated infection of cell cultures or animals, are placed into clusters, on the basis of a similar pattern of expression to other genes in that cluster; lines represent an individual transcript. As can be seen, this type of analysis can quickly determine groups of transcripts which may associate with pathogenesis or protection.
