Direct Microbicidal Activity of Cytotoxic T-Lymphocytes

Figure 3

CD8⁺T cells are primed for microbicidal activity following stimulation with C. neoformans mitogen (CnM). Recognition of CnM (presented by accessory cells) by CD4⁺T cells triggers their activation and proliferation. Meanwhile, a reciprocal signal from CD4⁺T cells mediated through an unknown receptor-ligand interaction (?) induces accessory cells to express IL-15, which in turn primes CD8⁺T cells for granulysin expression and anticryptococcal activity.