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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 250563, 10 pages
Dendritic Cells in the Gut: Interaction with Intestinal Helminths
1Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Avenue Universidad 3000, Colonia Copilco Universidad, México DF 04510, Mexico
2Escuela de Ciencias de la Salud, Universidad Anáhuac México Norte, Avenue Universidad Anáhuac 46, Huixquilucan, 52786 Estado de México, Mexico
Received 22 August 2009; Revised 30 November 2009; Accepted 18 December 2009
Academic Editor: Luis I. Terrazas
Copyright © 2010 Fela Mendlovic and Ana Flisser. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- R. M. Steinman and Z. A. Cohn, “Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution,” Journal of Experimental Medicine, vol. 137, no. 5, pp. 1142–1162, 1973.
- A. Iwasaki, “Mucosal dendritic cells,” Annual Review of Immunology, vol. 25, pp. 381–418, 2007.
- J. L. Coombes and F. Powrie, “Dendritic cells in intestinal immune regulation,” Nature Reviews Immunology, vol. 8, no. 6, pp. 435–446, 2008.
- P. J. Hotez, P. J. Brindley, J. M. Bethony, C. H. King, E. J. Pearce, and J. Jacobson, “Helminth infections: the great neglected tropical diseases,” Journal of Clinical Investigation, vol. 118, no. 4, pp. 1311–1321, 2008.
- R. M. Maizels, “Infections and allergy-helminths, hygiene and host immune regulation,” Current Opinion in Immunology, vol. 17, no. 6, pp. 656–661, 2005.
- M. J. G. Johnston, J. A. MacDonald, and D. M. McKay, “Parasitic helminths: a pharmacopeia of anti-inflammatory molecules,” Parasitology, vol. 136, no. 2, pp. 125–147, 2009.
- L. Carvalho, J. Sun, C. Kane, F. Marshall, C. Krawczyk, and E. J. Pearce, “Review series on helminths, immune modulation and the hygiene hypothesis: mechanisms underlying helminth modulation of dendritic cell function,” Immunology, vol. 126, no. 1, pp. 28–34, 2009.
- A. J. Stagg, A. L. Hart, S. C. Knight, and M. A. Kamm, “The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria,” Gut, vol. 52, no. 10, pp. 1522–1529, 2003.
- B. L. Kelsall and M. Rescigno, “Mucosal dendritic cells in immunity and inflammation,” Nature Immunology, vol. 5, no. 11, pp. 1091–1095, 2004.
- A. Iwasaki and B. L. Kelsall, “Unique functions of CD11b+, CD8+, and double-negative Peyer's patch dendritic cells,” Journal of Immunology, vol. 166, no. 8, pp. 4884–4890, 2001.
- Y. Kanamori, K. Ishimaru, M. Nanno, et al., “Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop,” Journal of Experimental Medicine, vol. 184, no. 4, pp. 1449–1459, 1996.
- D. Bouskra, C. Brézillon, M. Bérard, et al., “Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis,” Nature, vol. 456, no. 7221, pp. 507–510, 2008.
- K. Fujihashi, P. B. Boyaka, and J. R. McGGhee, “Host defences at mucosal surfaces,” in Clinical Immunology Principles and Practice, R. R. Rich, Ed., pp. 287–303, Mosby, St. Louis, Miss, USA, 2008.
- S. I. Hammerschmidt, M. Ahrendt, U. Bode, et al., “Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo,” Journal of Experimental Medicine, vol. 205, no. 11, pp. 2483–2490, 2008.
- G. Gorfu, J. Rivera-Nieves, and K. Ley, “Role of 7 integrins in intestinal lymphocyte homing and retention,” Current Molecular Medicine, vol. 9, no. 7, pp. 836–850, 2009.
- A. Hahn, N. Thiessen, R. Pabst, M. Buettner, and U. Bode, “Mesenteric lymph nodes are not required for an intestinal immunoglobulin A response to oral cholera toxin,” Immunology, vol. 129, no. 3, pp. 427–436, 2009.
- S. Fagarasan, K. Kinoshita, M. Muramatsu, K. Ikuta, and T. Honjo, “In situ class switching and differentiation to IgA-producing cells in the gut lamina propria,” Nature, vol. 413, no. 6856, pp. 639–643, 2001.
- H. Kiyono, J. Kunisawa, J. R. McGhee, and J. Mestecky, “The mucosal immune system,” in Fundamental Immunology, William E. Paul, 6th edition, 2008.
- K. Shortman and Y.-J. Liu, “Mouse and human dendritic cell subtypes,” Nature Reviews Immunology, vol. 2, no. 3, pp. 151–161, 2002.
- J. A. Villadangos and P. Schnorrer, “Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo,” Nature Reviews Immunology, vol. 7, no. 7, pp. 543–555, 2007.
- J. A. Villadangos and L. Young, “Antigen-presentation properties of plasmacytoid dendritic cells,” Immunity, vol. 29, no. 3, pp. 352–361, 2008.
- H. Ueno, E. Klechevsky, R. Morita, et al., “Dendritic cell subsets in health and disease,” Immunological Reviews, vol. 219, no. 1, pp. 118–142, 2007.
- A. Flores-Langarica, S. Meza-Perez, J. Calderon-Amador, et al., “Network of dendritic cells within the muscular layer of the mouse intestine,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 52, pp. 19039–19044, 2005.
- A. Iwasaki and B. L. Kelsall, “Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells,” Journal of Experimental Medicine, vol. 190, no. 2, pp. 229–239, 1999.
- K. A. Kadaoui and B. Corthésy, “Secretory IgA mediates bacterial translocation to dendritic cells in mouse Peyer's patches with restriction to mucosal compartment,” Journal of Immunology, vol. 179, no. 11, pp. 7751–7757, 2007.
- F. G. Chirdo, O. R. Millington, H. Beacock-Sharp, and A. M. Mowat, “Immunomodulatory dendritic cells in intestinal lamina propria,” European Journal of Immunology, vol. 35, no. 6, pp. 1831–1840, 2005.
- S. Uematsu, K. Fujimoto, M. H. Jang, et al., “Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5,” Nature Immunology, vol. 9, no. 7, pp. 769–776, 2008.
- M. H. Jang, N. Sougawa, T. Tanaka, et al., “CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes,” Journal of Immunology, vol. 176, no. 2, pp. 803–810, 2006.
- J. L. Coombes, K. R. R. Siddiqui, C. V. Arancibia-Cárcamo, et al., “A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF- -and retinoic acid-dependent mechanism,” Journal of Experimental Medicine, vol. 204, no. 8, pp. 1757–1764, 2007.
- C.-M. Sun, J. A. Hall, R. B. Blank, et al., “Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid,” Journal of Experimental Medicine, vol. 204, no. 8, pp. 1775–1785, 2007.
- E. Jaensson, H. Uronen-Hansson, O. Pabst, et al., “Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans,” Journal of Experimental Medicine, vol. 205, no. 9, pp. 2139–2149, 2008.
- J. R. Mora, M. Iwata, B. Eksteen, et al., “Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells,” Science, vol. 314, no. 5802, pp. 1157–1160, 2006.
- M. Rescigno, M. Urbano, B. Valzasina, et al., “Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria,” Nature Immunology, vol. 2, no. 4, pp. 361–367, 2001.
- J. Bilsborough, T. C. George, A. Norment, and J. L. Viney, “Mucosal CD8+ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties,” Immunology, vol. 108, no. 4, pp. 481–492, 2003.
- C. Johansson and B. L. Kelsall, “Phenotype and function of intestinal dendritic cells,” Seminars in Immunology, vol. 17, no. 4, pp. 284–294, 2005.
- F.-P. Huang, N. Platt, M. Wykes, et al., “A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes,” Journal of Experimental Medicine, vol. 191, no. 3, pp. 435–443, 2000.
- N. Contractor, J. Louten, L. Kim, C. A. Biron, and B. L. Kelsall, “Cutting edge: Peyer's patch plasmacytoid dendritic cells (pDCs) produce low levels of type I interferons: possible role for IL-10, TGF, and prostaglandin E2 in conditioning a unique mucosal pDC phenotype,” Journal of Immunology, vol. 179, no. 5, pp. 2690–2694, 2007.
- R. M. Maizels and M. Yazdanbakhsh, “Immune regulation by helminth parasites: cellular and molecular mechanisms,” Nature Reviews Immunology, vol. 3, no. 9, pp. 733–744, 2003.
- R. M. Maizels, A. Balic, N. Gomez-Escobar, M. Nair, M. D. Taylor, and J. E. Allen, “Helminth parasites–masters of regulation,” Immunological Reviews, vol. 201, pp. 89–116, 2004.
- S. R. Silva, J. F. Jacysyn, M. S. Macedo, and E. L. Faquin-Mauro, “Immunosuppressive components of Ascaris suum down-regulate expression of costimulatory molecules and function of antigen-presenting cells via an IL-10-mediated mechanism,” European Journal of Immunology, vol. 36, no. 12, pp. 3227–3237, 2006.
- C.-C. Chen, S. Louie, B. A. McCormick, W. A. Walker, and H. N. Shi, “Helminth-primed dendritic cells alter the host response to enteric bacterial infection,” Journal of Immunology, vol. 176, no. 1, pp. 472–483, 2006.
- H. N. Shi, H. Y. Liu, and C. Nagler-Anderson, “Enteric infection acts as an adjuvant for the response to a model food antigen,” Journal of Immunology, vol. 165, no. 11, pp. 6174–6182, 2000.
- M. Segura, Z. Su, C. Piccirillo, and M. M. Stevenson, “Impairment of dendritic cell function by excretory-secretory products: a potential mechanism for nematode-induced immunosuppression,” European Journal of Immunology, vol. 37, no. 7, pp. 1887–1904, 2007.
- R. T. Fujiwara, G. G. L. Cançado, P. A. Freitas, et al., “Necator americanus infection: a possible cause of altered dendritic cell differentiation and eosinophil profile in chronically infected individuals,” PLoS Neglected Tropical Diseases, vol. 3, no. 3, article e399, 2009.
- A. Balic, Y. Harcus, M. J. Holland, and R. M. Maizels, “Selective maturation of dendritic cells by Nippostrongylus brasiliensis-secreted proteins drives Th2 immune responses,” European Journal of Immunology, vol. 34, no. 11, pp. 3047–3059, 2004.
- A. Balic, K. A. Smith, Y. Harcus, and R. M. Maizels, “Dynamics of CD11c+ dendritic cell subsets in lymph nodes draining the site of intestinal nematode infection,” Immunology Letters, vol. 127, no. 1, pp. 68–75, 2009.
- K. Koyama, “Dendritic cell expansion occurs in mesenteric lymph nodes of B10.BR mice infected with the murine nematode parasite Trichuris muris,” Parasitology Research, vol. 97, no. 3, pp. 186–190, 2005.
- K. Koyama, “Erratum: dendritic cell expansion occurs in mesenteric lymph nodes of B10.BR mice infected with the murine nematode parasite Trichuris muris,” Parasitology Research, vol. 97, no. 3, p. 258, 2005.
- K. Koyama, “Dendritic cells have a crucial role in the production of cytokines in mesenteric lymph nodes of B10.BR mice infected with Trichuris muris,” Parasitology Research, vol. 102, no. 3, pp. 349–356, 2008.
- R. D'Elia and K. J. Else, “In vitro antigen presenting cell-derived IL-10 and IL-6 correlate with Trichuris muris isolate-specific survival,” Parasite Immunology, vol. 31, no. 3, pp. 123–131, 2009.
- C. Zaph, A. E. Troy, B. C. Taylor, et al., “Epithelial-cell-intrinsic IKK- expression regulates intestinal immune homeostasis,” Nature, vol. 446, no. 7135, pp. 552–556, 2007.
- B. C. Taylor, C. Zaph, A. E. Troy, et al., “TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis,” Journal of Experimental Medicine, vol. 206, no. 3, pp. 655–667, 2009.
- H. Helmby, K. Takeda, S. Akira, and R. K. Grencis, “Interleukin (IL)-18 promotes the development of chronic gastrointestinal helminth infection by downregulating IL-13,” Journal of Experimental Medicine, vol. 194, no. 3, pp. 355–364, 2001.
- W. C. Gause, J. F. Urban Jr., and M. J. Stadecker, “The immune response to parasitic helminths: insights from murine models,” Trends in Immunology, vol. 24, no. 5, pp. 269–277, 2003.
- S. M. Cruickshank, M. L. Deschoolmeester, M. Svensson, et al., “Rapid dendritic cell mobilization to the large intestinal epithelium is associated with resistance to Trichuris muris infection,” Journal of Immunology, vol. 182, no. 5, pp. 3055–3062, 2009.
- L. R. Schopf, K. F. Hoffmann, A. W. Cheever, J. F. Urban Jr., and T. A. Wynn, “IL-10 is critical for host resistance and survival during gastrointestinal helminth infection,” Journal of Immunology, vol. 168, no. 5, pp. 2383–2392, 2002.
- A. S. MacDonald and R. M. Maizels, “Alarming dendritic cells for Th2 induction,” Journal of Experimental Medicine, vol. 205, no. 1, pp. 13–17, 2008.
- D. Jankovic, S. Steinfelder, M. C. Kullberg, and A. Sher, “Mechanisms underlying helminth-induced Th2 polarization: default, negative or positive pathways?” Chemical Immunology and Allergy, vol. 90, pp. 65–81, 2006.
- G. Grutz, “New insights into the molecular mechanism of interleukin-10-mediated immunosuppression,” Journal of Leukocyte Biology, vol. 77, no. 1, pp. 3–15, 2005.
- H. H. Smits, E. C. de Jong, E. A. Wierenga, and M. L. Kapsenberg, “Different faces of regulatory DCs in homeostasis and immunity,” Trends in Immunology, vol. 26, no. 3, pp. 123–129, 2005.
- M. Whelan, M. M. Harnett, K. M. Houston, V. Patel, W. Harnett, and K. P. Rigley, “A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells,” Journal of Immunology, vol. 164, no. 12, pp. 6453–6460, 2000.
- S. Ferret-Bernard, R. S. Curwen, and A. P. Mountford, “Proteomic profiling reveals that Th2-inducing dendritic cells stimulated with helminth antigens have a ‘limited maturation’ phenotype,” Proteomics, vol. 8, no. 5, pp. 980–993, 2008.
- F. Granucci, C. Vizzardelli, E. Virzi, M. Rescigno, and P. Ricciardi-Castagnoli, “Transcriptional reprogramming of dendritic cells by differentiation stimuli,” European Journal of Immunology, vol. 31, no. 9, pp. 2539–2546, 2001.
- S. Józefowski, M. Arredouani, T. Sulahian, and L. Kobzik, “Disparate regulation and function of the class A scavenger receptors SR-AI/II and MARCO,” Journal of Immunology, vol. 175, no. 12, pp. 8032–8041, 2005.
- J. Rzepecka, S. Rausch, C. Klotz, et al., “Calreticulin from the intestinal nematode Heligmosomoides polygyrus is a Th2-skewing protein and interacts with murine scavenger receptor-A,” Molecular Immunology, vol. 46, no. 6, pp. 1109–1119, 2009.
- T. Ito, Y.-H. Wang, O. Duramad, et al., “TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand,” Journal of Experimental Medicine, vol. 202, no. 9, pp. 1213–1223, 2005.
- G. Tang, Q. Qin, P. Zhang, et al., “Reverse signaling using an inducible costimulator to enhance immunogenic function of dendritic cells,” Cellular and Molecular Life Sciences, vol. 66, no. 18, pp. 3067–3080, 2009.
- R. I. Nurieva, J. Duong, H. Kishikawa, et al., “Transcriptional regulation of Th2 differentiation by inducible costimulator,” Immunity, vol. 18, no. 6, pp. 801–811, 2003.
- I. L. King and M. Mohrs, “IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells,” Journal of Experimental Medicine, vol. 206, no. 5, pp. 1001–1007, 2009.
- J. C. Massacand, R. C. Stettler, R. Meier, et al., “Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 33, pp. 13968–13973, 2009.
- G. Parthasarathy and L. S. Mansfield, “Trichuris suis excretory secretory products (ESP) elicit interleukin-6 (IL-6) and IL-10 secretion from intestinal epithelial cells (IPEC-1),” Veterinary Parasitology, vol. 131, no. 3-4, pp. 317–324, 2005.