Statistical Analysis of Variation in the Human Plasma Proteome

Figure 4

Hierarchical clustering of the 33 samples (𝑦-axis) based on the abundance of the 397 high-quality protein spots on the 𝑥-axis, using Euclidean distance and average linkage. The samples are in SubjectNumberTime format, where SubjectNumber ranges from 01 to 11, and the Time values {x, y, and z } correspond to {𝑇₁, 𝑇₂, and 𝑇₃}. The intensities range from −1.5-fold change (bright green) to 1.5-fold change (bright red). The dendrogram on the right indicates the order of the sample grouping, with more similar samples being grouped together first. The color band on the left shows the genders of the samples, with red for females, and blue for males.