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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 263810, 10 pages
Immune Response of Cytotoxic T Lymphocytes and Possibility of Vaccine Development for Hepatitis C Virus Infection
Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan
Received 11 November 2009; Revised 25 January 2010; Accepted 15 March 2010
Academic Editor: Zhengguo Xiao
Copyright © 2010 Kazumasa Hiroishi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Q.-L. Choo, G. Kuo, A. J. Weiner, L. R. Overby, D. W. Bradley, and M. Houghton, “Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome,” Science, vol. 244, no. 4902, pp. 359–362, 1989.
- K. L. Yap, G. L. Ada, and I. F. C. McKenzie, “Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus,” Nature, vol. 273, no. 5659, pp. 238–239, 1978.
- R. M. Zinkernagel, E. Haenseler, T. Leist, A. Cerny, H. Hengartner, and A. Althage, “T cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I-restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay?” Journal of Experimental Medicine, vol. 164, no. 4, pp. 1075–1092, 1986.
- C. E. Samuel, “Antiviral actions of interferons,” Clinical Microbiology Reviews, vol. 14, no. 4, pp. 778–809, 2001.
- Y.-J. Liu, H. Kanzler, V. Soumelis, and M. Gilliet, “Dendritic cell lineage, plasticity and cross-regulation,” Nature Immunology, vol. 2, no. 7, pp. 585–589, 2001.
- H. Watarai, E. Sekine, S. Inoue, R. Nakagawa, T. Kaisho, and M. Taniguchi, “PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 8, pp. 2993–2998, 2008.
- A. Ahmad and F. Alvarez, “Role of NK and NKT cells in the immunopathogenesis of HCV-induced hepatitis,” Journal of Leukocyte Biology, vol. 76, no. 4, pp. 743–759, 2004.
- J. Banchereau and R. M. Steinman, “Dendritic cells and the control of immunity,” Nature, vol. 392, no. 6673, pp. 245–252, 1998.
- D. Kägi, F. Vignaux, B. Ledermann, et al., “Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity,” Science, vol. 265, no. 5171, pp. 528–530, 1994.
- H. Kojima, N. Shinohara, S. Hanaoka, et al., “Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes,” Immunity, vol. 1, no. 5, pp. 357–364, 1994.
- K. Ando, K. Hiroishi, T. Kaneko, et al., “Perforin, Fas/Fas ligand, and TNF- pathways as specific and bystander killing mechanisms of hepatitis C virus-specific human CTL,” Journal of Immunology, vol. 158, no. 11, pp. 5283–5291, 1997.
- K. Ando, T. Moriyama, L. G. Guidotti, et al., “Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis,” Journal of Experimental Medicine, vol. 178, no. 5, pp. 1541–1554, 1993.
- H. Doi, K. Hiroishi, T. Shimazaki, et al., “Magnitude of T-cell responses against hepatitis C virus and severity of hepatitis do not necessarily determine outcomes in acute hepatitis C virus infection,” Hepatology Research, vol. 39, no. 3, pp. 256–265, 2009.
- G. M. Lauer, E. Barnes, M. Lucas, et al., “High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection,” Gastroenterology, vol. 127, no. 3, pp. 924–936, 2004.
- D. Yerly, D. Heckerman, T. M. Allen, et al., “Increased cytotoxic T-lymphocyte epitope variant cross-recognition and functional avidity are associated with hepatitis C virus clearance,” Journal of Virology, vol. 82, no. 6, pp. 3147–3153, 2008.
- K. Hiroishi, H. Kita, M. Kojima, et al., “Cytotoxic T lymphocyte response and viral load in hepatitis C virus infection,” Hepatology, vol. 25, no. 3, pp. 705–712, 1997.
- S. Zeuzem, “Hepatitis C virus: kinetics and quasispecies evolution during anti-viral therapy,” Forum, vol. 10, no. 1, pp. 32–42, 2000.
- S. Guglietta, A. R. Garbuglia, L. Salichos, et al., “Impact of viral selected mutations on T cell mediated immunity in chronically evolving and self limiting acute HCV infection,” Virology, vol. 386, no. 2, pp. 398–406, 2009.
- A. L. Hughes, M. A. K. Hughes, and R. Friedman, “Variable intensity of purifying selection on cytotoxic T-lymphocyte epitopes in hepatitis C virus,” Virus Research, vol. 123, no. 2, pp. 147–153, 2007.
- A. Maki, M. Matsuda, M. Asakawa, H. Kono, H. Fujii, and Y. Matsumoto, “Decreased CD3 molecules of T lymphocytes from patients with hepatocellular carcinoma associated with hepatitis C virus,” Hepatology Research, vol. 27, no. 4, pp. 272–278, 2003.
- G. Missale, E. Cariani, and C. Ferrari, “Role of viral and host factors in HCV persistence: which lesson for therapeutic and preventive strategies?” Digestive and Liver Disease, vol. 36, no. 11, pp. 703–711, 2004.
- V. Francavilla, D. Accapezzato, M. De Salvo, et al., “Subversion of effector T cell differentiation in acute hepatitis C virus infection: exploring the immunological mechanisms,” European Journal of Immunology, vol. 34, no. 2, pp. 427–437, 2004.
- S. Urbani, B. Amadei, D. Tola, et al., “PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion,” Journal of Virology, vol. 80, no. 22, pp. 11398–11403, 2006.
- L. Golden-Mason, B. Palmer, J. Klarquist, J. A. Mengshol, N. Castelblanco, and H. R. Rosen, “Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific T cells associated with reversible immune dysfunction,” Journal of Virology, vol. 81, no. 17, pp. 9249–9258, 2007.
- L. Golden-Mason, J. Klarquist, A. S. Wahed, and H. R. Rosen, “Cutting edge: programmed death-1 expression is increased on immunocytes in chronic hepatitis C virus and predicts failure of response to antiviral therapy: race-dependent differences,” Journal of Immunology, vol. 180, no. 6, pp. 3637–3641, 2008.
- N. Nakamoto, H. Cho, A. Shaked, et al., “Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade,” PLoS Pathogens, vol. 5, no. 2, Article ID e1000313, 2009.
- M. Kriegs, T. Bürckstümmer, K. Himmelsbach, et al., “The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivo,” Journal of Biological Chemistry, vol. 284, no. 41, pp. 28343–28351, 2009.
- Z. Q. Yao, D. T. Nguyen, A. I. Hiotellis, and Y. S. Hahn, “Hepatitis C virus core protein inhibits human T lymphocyte responses by a complement-dependent regulatory pathway,” Journal of Immunology, vol. 167, no. 9, pp. 5264–5272, 2001.
- D. J. Kittlesen, K. A. Chianese-Bullock, Z. Q. Yao, T. J. Braciale, and Y. S. Hahn, “Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation,” Journal of Clinical Investigation, vol. 106, no. 10, pp. 1239–1249, 2000.
- Z. Q. Yao, A. Eisen-Vandervelde, S. Ray, and Y. S. Hahn, “HCV core/gC1qR interaction arrests T cell cycle progression through stabilization of the cell cycle inhibitor p27Kip1,” Virology, vol. 314, no. 1, pp. 271–282, 2003.
- K. V. Konan, T. H. Giddings Jr., M. Ikeda, K. Li, S. M. Lemon, and K. Kirkegaard, “Nonstructural protein precursor NS4A/B from hepatitis C virus alters function and ultrastructure of host secretory apparatus,” Journal of Virology, vol. 77, no. 14, pp. 7843–7855, 2003.
- P. Sarobe, J. J. Lasarte, A. Zabaleta, et al., “Hepatitis C virus structural proteins impair dendritic cell maturation and inhibit in vivo induction of cellular immune responses,” Journal of Virology, vol. 77, no. 20, pp. 10862–10871, 2003.
- G. Szabo and A. Dolganiuc, “Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection,” Immunobiology, vol. 210, no. 2–4, pp. 237–247, 2005.
- P.-Y. Lozach, H. Lortat-Jacob, A. de Lacroix de Lavalette, et al., “DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2,” Journal of Biological Chemistry, vol. 278, no. 22, pp. 20358–20366, 2003.
- S. Pöhlmann, J. Zhang, F. Baribaud, et al., “Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR,” Journal of Virology, vol. 77, no. 7, pp. 4070–4080, 2003.