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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 279391, 9 pages
Maintenance or Emergence of Chronic Phase Secondary Cytotoxic T Lymphocyte Responses after Loss of Acute Phase Immunodominant Responses Does Not Protect SIV-Infected Rhesus Macaques from Disease Progression
1University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA
2Department of Virology and Immunology, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA
3Poxvirus and Rabies Branch, Centers for Disease Control, 1600 Clifton Road MS-G06, Atlanta, GA 30333, USA
4Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, TX 78227-5301, USA
Received 30 November 2009; Revised 19 February 2010; Accepted 9 March 2010
Academic Editor: Kim Klonowski
Copyright © 2010 M. Shannon Keckler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- V. Appay, D. C. Douek, and D. A. Price, “CD8+ T cell efficacy in vaccination and disease,” Nature Medicine, vol. 14, no. 6, pp. 623–628, 2008.
- L. E. Valentine and D. I. Watkins, “Relevance of studying T cell responses in SIV-infected rhesus macaques,” Trends in Microbiology, vol. 16, no. 12, pp. 605–611, 2008.
- D. T. Evans, P. Jing, T. M. Allen, et al., “Definition of five new simian immunodeficiency virus cytotoxic t-lymphocyte epitopes and their restricting major histocompatibility complex class I molecules: evidence for an influence on disease progression,” Journal of Virology, vol. 74, no. 16, pp. 7400–7410, 2000.
- R. Pal, D. Venzon, N. L. Letvin, et al., “ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I () delay simian immunodeficiency virus SIVmac-induced immunodeficiency,” Journal of Virology, vol. 76, no. 1, pp. 292–302, 2002.
- G. M. A. Gillespie, R. Kaul, T. Dong, et al., “Cross-reactive cytotoxic T lymphocytes against a HIV-1 p24 epitope in slow progressors with ,” AIDS, vol. 16, no. 7, pp. 961–972, 2002.
- M. J. Kuroda, J. E. Schmitz, D. H. Barouch, et al., “Analysis of gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex,” Journal of Experimental Medicine, vol. 187, no. 9, pp. 1373–1381, 1998.
- W. R. Morton, M. B. Agy, S. V. Capuano, and R. F. Grant, “Specific pathogen-free macaques: definition, history, and current production,” ILAR Journal, vol. 49, no. 2, pp. 137–144, 2008.
- L. J. Yant, T. C. Friedrich, R. C. Johnson, et al., “The high-frequency major histocompatibility complex class I allele Mamu- is associated with control of simian immunodeficiency virus SIVmac239 replication,” Journal of Virology, vol. 80, no. 10, pp. 5074–5077, 2006.
- J. A. Wojcechowskyj, L. J. Yant , R. W. Wiseman, S. L. O'Connor, and D. H. O'Connor, “Control of simian immunodeficiency virus SIVmac239 is not predicted by inheritance of Mamu--containing haplotypes,” Journal of Virology, vol. 81, pp. 406–410, 2007.
- J. T. Loffredo, J. Maxwell, Y. Qi, et al., “Mamu--positive macaques control simian immunodeficiency virus replication,” Journal of Virology, vol. 81, pp. 8827–8832, 2007.
- X. G. Yu, M. M. Addo, E. S. Rosenberg, et al., “Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection,” Journal of Virology, vol. 76, no. 17, pp. 8690–8701, 2002.
- R. Draenert, T. M. Allen, Y. Liu, et al., “Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus,” Journal of Experimental Medicine, vol. 203, no. 3, pp. 529–539, 2006.
- S. Tenzer, E. Wee, A. Burgevin, et al., “Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance,” Nature Immunology, vol. 10, no. 6, pp. 636–646, 2009.
- C. L. Day, A. K. Shea, M. A. Altfeld, et al., “Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles,” Journal of Virology, vol. 75, no. 14, pp. 6279–6291, 2001.
- I. Messaoudi, J. A. Guevara Patiño, R. Dyall, J. LeMaoult, and J. Nikolich-Zugich, “Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense,” Science, vol. 298, no. 5599, pp. 1797–1800, 2002.
- A. Hasegawa, C. Moriya, H. Liu, et al., “Analysis of TCR combinations used by simian immunodeficiency virus-specific CD8+ T cells in rhesus monkeys: implications for CTL immunodominance,” Journal of Immunology, vol. 178, no. 6, pp. 3409–3417, 2007.
- K. C. Pang, M. T. Sanders, J. J. Monaco, P. C. Doherty, S. J. Turner, and W. Chen, “Immunoproteasome subunit deficiencies impact differentially on two immunodominant influenza virus-specific CD8+ T cell responses,” Journal of Immunology, vol. 177, no. 11, pp. 7680–7688, 2006.
- M. F. Kotturi, I. Scott, T. Wolfe, et al., “Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance,” Journal of Immunology, vol. 181, no. 3, pp. 2124–2133, 2008.
- C. Brander, N. Frahm, and B. D. Walker, “The challenges of host and viral diversity in HIV vaccine design,” Current Opinion in Immunology, vol. 18, no. 4, pp. 430–437, 2006.
- D. O'Connor, T. Friedrich, A. Hughes, T. M. Allen, and D. Watkins, “Understanding cytotoxic T-lymphocyte escape during simian immunodeficiency virus infection,” Immunological Reviews, vol. 183, pp. 115–126, 2001.
- D. H. O'Connor, T. M. Allen, T. U. Vogel, et al., “Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection,” Nature Medicine, vol. 8, no. 5, pp. 493–499, 2002.
- D. A. Price, S. M. West, M. R. Betts, et al., “T cell receptor recognition motifs govern immune escape patterns in acute SIV infection,” Immunity, vol. 21, no. 6, pp. 793–803, 2004.
- J. T. Loffredo, T. C. Friedrich, E. J. Leon, et al., “CD8+ T cells from SIV elite controller macaques recognize Mamu--bound epitopes and select for widespread viral variation,” PLoS One, vol. 2, article e1152, 2007.
- A. B. McDermott, D. H. O'Connor, S. Fuenger, et al., “Cytotoxic T-lymphocyte escape does not always explain the transient control of simian immunodeficiency virus SIVmac239 viremia in adenovirus-boosted and DNA-primed Mamu--positive rhesus macaques,” Journal of Virology, vol. 79, pp. 15556–15566, 2005.
- N. J. Maness, L. J. Yant, and C. Chung, “Comprehensive immunological evaluation reveals surprisingly few differences between elite controller and progressor Mamu--positive Simian immunodeficiency virus-infected rhesus macaques,” Journal of Virology, vol. 82, pp. 5245–5254, 2008.
- Z. W. Chen, A. Craiu, L. Shen, et al., “Simian immunodeficiency virus evades a dominant epitope-specific cytotoxic T lymphocyte response through a mutation resulting in the accelerated dissociation of viral peptide and MHC class I,” Journal of Immunology, vol. 164, no. 12, pp. 6474–6479, 2000.
- F. W. Peyerl, D. H. Barouch, W. W. Yeh, et al., “Simian-human immunodeficiency virus escape from cytotoxic T-lymphocyte recognition at a structurally constrained epitope,” Journal of Virology, vol. 77, no. 23, pp. 12572–12578, 2003.
- T. C. Friedrich, E. J. Dodds, L. J. Yant, et al., “Reversion of CTL escape-variant immunodeficiency viruses in vivo,” Nature Medicine, vol. 10, no. 3, pp. 275–281, 2004.
- T. C. Friedrich, C. A. Frye, L. J. Yant, et al., “Extraepitopic compensatory substitutions partially restore fitness to simian immunodeficiency virus variants that escape from an immunodominant cytotoxic-T-lymphocyte response,” Journal of Virology, vol. 78, no. 5, pp. 2581–2585, 2004.
- M. Kobayashi, H. Igarashi, A. Takeda, M. Kato, and T. Matano, “Reversion in vivo after inoculation of a molecular proviral DNA clone of simian immunodeficiency virus with a cytotoxic-T-lymphocyte escape mutation,” Journal of Virology, vol. 79, no. 17, pp. 11529–11532, 2005.
- V. L. Hodara, M. Velasquillo, L. M. Parodi, and L. D. Giavedoni, “Expression of CD154 by a simian immunodeficiency virus vector induces only transitory changes in rhesus macaques,” Journal of Virology, vol. 79, no. 8, pp. 4679–4690, 2005.
- M. S. Keckler, V. L. Hodara, L. M. Parodi, and L. D. Giavedoni, “Novel application of nonhuman primate tethering system for evaluation of acute phase SIVmac251 infection in rhesus macaques (macaca mulatta),” Viral Immunology, vol. 20, pp. 623–634, 2007.
- D. R. Johnson, “Differential expression of human major histocompatibility class I loci: HLA-A,-B, and -C,” Human Immunology, vol. 61, no. 4, pp. 389–396, 2000.
- M. Kaizu, G. J. Borchardt, C. E. Glidden, et al., “Molecular typing of major histocompatibility complex class I alleles in the Indian rhesus macaque which restrict SIV CD8+ T cell epitopes,” Immunogenetics, vol. 59, no. 9, pp. 693–703, 2007.
- Z. W. Chen, H. Yamamoto, D. I. Watkins, G. Levinson, and N. L. Letvin, “Predominant use of a T-cell receptor V gene family in simian immunodeficiency virus gag-specific cytotoxic T lymphocytes in a rhesus monkey,” Journal of Virology, vol. 66, no. 6, pp. 3913–3917, 1992.
- M. Newberg, M. Kuroda, and W. Charini, “A simian immunodeficiency virus nef Peptide is a dominant cytotoxic T lymphocyte epitope in Indian-origin rhesus monkeys expressing the common MHC class I allele mamu-,” Virology, pp. 301–365, 2002.
- D. H. Barouch, J. Kunstman, M. J. Kuroda, et al., “Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lynphocytes,” Nature, vol. 415, no. 6869, pp. 335–339, 2002.
- A. Oxenius, D. A. Price, A. Trkola, et al., “Loss of viral control in early HIV-1 infection is temporally associated with sequential escape from CD8+ T cell responses and decrease in HIV-1-specific CD4+ and CD8+ T cell frequencies,” Journal of Infectious Diseases, vol. 190, no. 4, pp. 713–721, 2004.
- H. Streeck, J. S. Jolin, Y. Qi, et al., “Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells,” Journal of Virology, vol. 83, no. 15, pp. 7641–7648, 2009.
- N. Frahm, P. Kiepiela, S. Adams, et al., “Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes,” Nature Immunology, vol. 7, no. 2, pp. 173–178, 2006.
- J. H. Simon, A. M. Sheehy, E. A. Carpenter, R. A. Fouchier, and M. H. Malim, “Mutational analysis of the human immunodeficiency virus type 1 Vif protein,” Journal of Virology, vol. 73, no. 4, pp. 2675–2681, 1999.
- Y. E. Wang, B. Li, J. M. Carlson, et al., “Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1,” Journal of Virology, vol. 83, no. 4, pp. 1845–1855, 2009.
- Z. L. Brumme, C. J. Brumme, and D. Heckerman, “Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1,” PLoS Pathogens, vol. 3, article e94, 2007.