Research Article

Maintenance or Emergence of Chronic Phase Secondary Cytotoxic T Lymphocyte Responses after Loss of Acute Phase Immunodominant Responses Does Not Protect SIV-Infected Rhesus Macaques from Disease Progression

Table 1

MHC class I allele and CTL Epitope Summary.

Animal NumberVaccination, Disease ProgressionMamu allelesCTL EpitopeSignificant Trend in CTL ResponseEmergence of viral mutantsRestricting Allele for CTL Epitope

16037LAV, LTNP 𝐀 𝟎 𝟏 [ 1 ] , A 0 2 , A 0 4 ,Gag CTPYDINQ M IncreasingNo A 01
B 07, B 09 V [ 2 ] Tat STPESANLIncreasingNo A 01
16041LAV, LTNP 𝐀 01, A 2 3 , B alleles notGag CTPYDINQ M IncreasingUnknown A 01
determinedTat STPESANLDecreasingUnknown A 01
14757None, LTNP 𝐀 𝟎 𝟏 , A 0 4 , A 23 V,Gag CTPYDINQ M IncreasingNo A 01
B 07, 𝐁 08Nef RRLTARGLLIncreasingNo B 08
Tat STPESANLIncreasingYes A 01
Gag TAPSSGRGGNYIncreasingNoUnknown
16044LAV, SP A 04 V, A 23, B 3002 V,Vif YFPCFTAGEV R *PDecreasingYesUnknown
B 09 V, B 21, B 49Gag EQIQWMYRQ Q P DecreasingNoUnknown
Gag MYNPTNILDV K P IncreasingNoUnknown
16040LAV, NP (118 W) 𝐀 01, A 23 V, B 63NGag CTPYDINQ M DecreasingYes A 01
12416None, NP (52 W) A 04, A 25  N [ 3 ] , B 67Nef RTMSYKLAID M P IncreasingYesUnknown
11896None, RP (12 W)NDNDNDNDND
12900None, RP (16 W) A 02, A 02 V, A 04, B 05 V, B 07NDNDNDND

LAV: live-attenuated vaccine, LTNP: long-term non progressor, SP: slow prog., NP: normal prog., RP: rapid prog., (time of euthanasia in weeks post-challenge).
[ 1 ] B o l d e d alleles have been reported as protective.
[ 2 ] V a r i a n t (less than 5 amino acid changes in α1 and α2 domains from published sequence of allele listed).
[ 3 ] N o v e l (more than 5 amino acid differences in α1 and α2 domains from published sequence of allele listed).
P P utative Epitope, I mmunodominant Epitope.