A Multifactorial Mechanism in the Superior Antimalarial Activity of 𝛼-C-GalCer

Figure 1

Structural comparison between 𝛼-C-GalCer and 𝛼-GalCer showing the main differences between the two molecules. Glycoside CH₂ is nonpolar and hydrophobic; it repels hydrogen bond donors. In contrast, glycoside oxygen is polar, and the electron pairs can form hydrogen bonds with N–H or O–H donors.