A Multifactorial Mechanism in the Superior Antimalarial Activity of -C-GalCer
Figure 3
-C-GalCer’s superior antimalarial activity does not involve IL-4 or IL-10. (a) Groups of 5 WT or IL-4-deficient BALB/c mice, or (b) groups of 5 WT or IL-10-deficient C57BL/6 mice, were treated i.p. with 1 g of either -C-GalCer or -GalCer or with nothing 3 days before challenge with live P. yoelii sporozoites, and then checked for malaria liver stage development. The results are expressed as the average SD of 5 mice. The data shown come from one of three experiments with similar results.
