Vaxign: The First Web-Based Vaccine Design Program for Reverse Vaccinology and Applications for Vaccine Development

<table>Vaxign prediction of UPEC vaccine targets. (a) Selection of <i>E. coli</i> CFT073 as a seed genome. Different filter options are applied: only outer membrane proteins, maximum of one transmembrane helix, minimum adhesin probability of.51, having orthologs in other three UPEC genomes but no orthologs in K-12 strain M1655, and no similarity to any human or mouse proteins. (b) In total 22 proteins were predicted to meet selected criteria. (c) Detailed results for a particular protein, for example, NmpC. MHC Class I and II epitope prediction results are also available and can be further filtered. (d) Prediction of <i>α</i>-helices and their possible cellular locations of NmpC. (e) Prediction of <svg height="13.425" id="M51" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 8.8500004 13.425" width="8.8500004" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.425)">
<g transform="translate(72,-61.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛽</tspan>
</text>
</g>
</g>
</svg>-barrels and their possible cellular locations of NmpC. </table>

BioMed Research International

fig3

Figure 3

Figure 3: Vaxign: The First Web-Based Vaccine Design Program for Reverse Vaccinology and Applications for Vaccine Development 