Vaxign: The First Web-Based Vaccine Design Program for Reverse Vaccinology and Applications for Vaccine Development

Table 2

Epitope prediction performance by Vaxitope as measured by AUC values.

#	MHC allele	Length	AUC	Sensitivity (𝑃=.01)	Specificity (𝑃=.01)	Sensitivity (𝑃=.05)	Specificity (𝑃=.05)	Sensitivity (𝑃=.1)	Specificity (𝑃=.1)
1	HLA-A∗0101	9	0.929	.854	.874	.99	.709	1	.621
2	HLA-A∗0201	9	0.871	.298	.956	.531	.876	.792	.783
3	HLA-A∗0201	10	0.913	.471	.957	.789	.874	.901	.773
4	HLA-A∗0202	9	0.869	.309	.953	.658	.875	.792	.774
5	HLA-A∗0202	10	0.863	.333	.949	.737	.808	.891	.684
6	HLA-A∗0203	9	0.874	.304	.956	.659	.865	.828	.769
7	HLA-A∗0203	10	0.867	.317	.963	.691	.827	.834	.712
8	HLA-A∗0206	9	0.900	.387	.961	.73	.867	.881	.781
9	HLA-A∗0206	10	0.916	.403	.957	.775	.878	.922	.782
10	HLA-A∗0301	9	0.887	.445	.921	.855	.803	.959	.69
11	HLA-A∗0301	10	0.868	.505	.9	.915	.706	.988	.554
12	HLA-A∗1101	9	0.863	.337	.946	.672	.833	.859	.71
13	HLA-A∗1101	10	0.879	.461	.924	.9	.742	.989	.627
14	HLA-A∗2402	9	0.984	.727	.985	.97	.879	1	.783
15	HLA-A∗3101	9	0.912	.426	.952	.813	.872	.927	.752
16	HLA-A∗3101	10	0.855	.419	.905	.889	.711	.99	.563
17	HLA-A∗3301	9	0.937	.495	.959	.94	.851	.989	.723
18	HLA-A∗3301	10	0.905	.51	.942	.905	.755	.966	.619
19	HLA-A∗6801	9	0.908	.406	.949	.841	.841	.946	.744
20	HLA-A∗6801	10	0.848	.418	.9	.866	.701	.973	.564
21	HLA-A∗6802	9	0.918	.446	.96	.801	.868	.922	.757
22	HLA-A∗6802	10	0.913	.452	.947	.837	.825	.977	.715
23	HLA-A∗6901	9	0.803	.279	.895	.674	.785	.837	.674
24	HLA-B∗0702	9	0.963	.659	.966	.962	.894	.981	.849
25	HLA-B∗1501	9	0.873	.514	.927	.816	.765	.939	.603
26	HLA-B∗3501	9	0.838	.403	.927	.701	.775	.834	.666
27	HLA-B∗5101	9	0.978	.835	.953	1	.871	1	.824
28	HLA-B∗5301	9	0.989	.84	.981	.991	.896	1	.825
29	HLA-B∗5801	9	0.923	.769	.933	.894	.813	.952	.702
30	H-2-Kb	8	0.936	.753	.922	.935	.744	.987	.623
31	H-2-IAd	---^∗	0.928	.582	.992	.705	.959	.82	.926
32	H-2-IEd	—	0.977	.903	1	.935	.935	.935	.887
33	H-2-IEg7	—	0.998	.993	.989	.993	.945	1	.893
34	H-2-IEk	—	0.940	.775	.95	.875	.9	.9	.813
35	HLA-DPB1∗0401	—	0.950	.717	.978	.826	.924	.913	.87
36	HLA-DPB1∗0901	—	0.978	.739	.989	.891	.913	.913	.859
37	HLA-DR1	—	0.923	.587	.972	.781	.915	.838	.834
38	HLA-DR7	—	0.990	.976	.988	.976	.905	.976	.845
39	HLA-DRB1∗1101	—	0.952	.732	.978	.828	.914	.898	.831
40	HLA-DRB1∗1501	—	0.951	.846	.981	.897	.942	.91	.872

Note: ∗ means flexible length.